109794-69-6Relevant articles and documents
Lipase-mediated resolution of 3-hydroxy-4-trityloxybutanenitrile: synthesis of 2-amino alcohols, oxazolidinones and GABOB
Kamal, Ahmed,Khanna, G.B. Ramesh,Krishnaji,Ramu
, p. 1281 - 1289 (2007/10/03)
Lipase-mediated kinetic resolution of 3-hydroxy-4-trityloxybutanenitrile gave the (S)-alcohol and (R)-acetate in good yields and high enantioselectivities. The resolution using Pseudomonas cepacia lipase (Burkholderia cepacia) immobilized on modified cera
The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class.
Sciotti, Richard J,Pliushchev, Marina,Wiedeman, Paul E,Balli, Darlene,Flamm, Robert,Nilius, Angela M,Marsh, Kennan,Stolarik, DeAnne,Jolly, Robert,Ulrich, Roger,Djuric, Stevan W
, p. 2121 - 2123 (2007/10/03)
A novel series of antimicrobials of the oxazolidinone class is disclosed. These compounds are characterized relative to previously described analogues by a 'halostilbene-derived' pharmacophore and demonstrate enhanced antimicrobial activity against key Gram-positive pathogens when compared to Linezolid.
Oxazolidinone chemotherapeutic agents
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, (2008/06/13)
Compounds of formula (I) or therapeutically acceptable salts or prodrugs thereof, are useful for treating bacterial infections, psoriasis, arthritis, and toxicity due to chemotherapy. Preparation of the compounds, compositions containing the compounds, an