109843-27-8

Basic information

• Product Name: N-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-2-carboxamide
• Synonyms: N-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-2-carboxamide
• CAS NO: 109843-27-8
• Molecular Weight: 295.295
• Mol File: 109843-27-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-2-carboxamide(109843-27-8)
• EPA Substance Registry System: N-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-2-carboxamide(109843-27-8)

Safety Data

• Hazardous Substances Data: 109843-27-8(Hazardous Substances Data)

Upstream product

• 4940-39-0 acide chromone carboxylique-2 
• 104-94-9 4-methoxy-aniline 
• 5112-47-0 4-oxo-4H-chromene-2-carbonyl chloride 

Relevant articles and documents

Synthesis and NMR studies of novel chromone-2-carboxamide derivatives

Chromones are heterocyclic compounds of natural or synthetic origin that possess relevant pharmacological activities. Versatile functionalization of the chromone nucleus allows attaining of a chemical diversity suitable to perform structure-activity relationships in drug discovery and development programs. Accordingly, the synthesis and identification of novel chromone carboxamide derivatives with electron-donating and electron-withdrawing substituents in different positions of the exocyclic ring are reported in this work. Their complete structural characterization was performed using one-dimensional and two-dimensional resonance techniques. The data acquired are useful for a prompt analysis of related compounds that encompass our integrated medicinal chemistry sketch. Copyright

Accelerating lead optimization of chromone carboxamide scaffold throughout microwave-assisted organic synthesis

Microwave irradiation offers a considerable advantage over conventional synthesis with rate enhancements and cleaner reactions. Accordingly, a new microwave-assisted method for the synthesis of func-tionalized chromones was developed allowing the obtention of a library of chromone carboxamides. The method has been shown to present several advantages including operational simplicity, good performance, significant reduction in reaction time, less formation of by-products, and easier work-up.