1098977-16-2

Basic information

• Product Name: 3',5'-di-O-trityl-5-chlorouridine
• Synonyms: 3',5'-di-O-trityl-5-chlorouridine
• CAS NO: 1098977-16-2
• Molecular Weight: 763.289
• Mol File: 1098977-16-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3',5'-di-O-trityl-5-chlorouridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-di-O-trityl-5-chlorouridine(1098977-16-2)
• EPA Substance Registry System: 3',5'-di-O-trityl-5-chlorouridine(1098977-16-2)

Safety Data

• Hazardous Substances Data: 1098977-16-2(Hazardous Substances Data)

Upstream product

• 58-96-8 uridine 
• 2880-89-9 5-chlorouridine 
• 76-83-5 trityl chloride 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 3370-68-1 2',3',5'-tri-O-acetyl-5-chlorouridine 
• 4105-38-8 Tri-O-acetyluridine 

Relevant articles and documents

In search of flavivirus inhibitors: Evaluation of different tritylated nucleoside analogues

Following up on a hit that was identified in a large scale cell-based antiviral screening effort, a series of triphenylmethyl alkylated nucleoside analogues were synthesized and evaluated for their in vitro antiviral activities against the dengue virus (DENV) and the yellow fever virus (YFV). Hereto, trityl moieties were attached at various positions of the sugar ring combined with subtle variations of the heterocyclic base. Several triphenylmethyl modified nucleosides were uncovered being endowed with submicromolar in vitro antiviral activity against the YFV. The most selective inhibitor in this series was 3′,5′-bis-O-tritylated-5-chlorouridine (1b) affording a selectivity index of over 90, whereas the 3′,5′-bis-O-tritylated inosine congener (5b) displayed the highest activity, but proved more toxic. The finding of these lipophilic structures being endowed with high antiviral activity for flaviviruses, should stimulate the interest for further structureeactivity research.