109908-77-2Relevant articles and documents
Metabolic Synthesis of Arylacetic Acid Antiinflammatory Drugs from Arylhexenoic Acids. 2. Indomethacin
Gillard, J. W.,Belanger, P.
, p. 2051 - 2058 (2007/10/02)
Arylacetic acid antiinflammatory drugs can be metabolically produced by β-oxidation of 6-arylhex-5-enoic acid side chain.Such a mechanism provides for an in vivo sustained release of the active principle indomethacin from 6-N-(p-chlorobenzoyl)-2-methylin