1099798-32-9

Basic information

• Product Name: C₂₄H₃₃N₂O₆P
• Synonyms: C₂₄H₃₃N₂O₆P
• CAS NO: 1099798-32-9
• Molecular Weight: 476.51
• Mol File: 1099798-32-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₃₃N₂O₆P(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₃₃N₂O₆P(1099798-32-9)
• EPA Substance Registry System: C₂₄H₃₃N₂O₆P(1099798-32-9)

Safety Data

• Hazardous Substances Data: 1099798-32-9(Hazardous Substances Data)

Upstream product

• 110497-20-6 N-(Diisopropyloxyphosphoryl)-Gly-OH 
• 586410-15-3 1-[(E)-2-(4-aminophenyl)ethenyl]-3,5-dimethoxybenzene 

Relevant articles and documents

The design, synthesis, and anti-tumor mechanism study of N-phosphoryl amino acid modified resveratrol analogues

A novel series of trans-N-phosphoryl amino acid modified resveratrol analogues were synthesized and evaluated in vitro for their cytotoxic effects against CNE-1 and CNE-2 cell lines. These analogues showed good anti-proliferative activity, among which 8d, 8e, 8j, and 9d displayed much stronger inhibition effect than resveratrol and 8d showed the most potent activity with IC50 value at 3.45 ± 0.82 μM. The anti-tumor effects of 8d, 8e, 8j, and 9d were due to the induction of apoptosis, confirmed by the DNA fragmentation and flow cytometry analysis using PI (propidium iodide) staining and Annexin-V-FITC/PI staining assay. The PI staining assay also showed that 8d, 8e, 8j, and 9d caused cell cycles arrest at G0-G1 phase which finally led to cell apoptosis. Further mechanism study on compound 8d against CNE-2 cells has shown the PARP cleavage, which is a hallmark of caspase-3 activation, as well as the activation of caspase-9, and the intracellular ROS generation. These results all suggest that 8d induced a mitochondrial-dependent apoptosis pathway.