1099828-11-1Relevant articles and documents
A flexible route to chiral 2-endo-substituted 9-oxabispidines and their application in the enantioselective oxidation of secondary alcohols
Breuning, Matthias,Steiner, Melanie,Mehler, Christian,Paasche, Alexander,Hein, David
supporting information; experimental part, p. 1407 - 1410 (2009/07/11)
A new and flexible route to enantiomerically pure bi-and tricyclic 9-oxabispidines has been developed with use of (1R,5S)-7-methyl-2-oxo-9-oxa-3,7- diazabicyclo[33.1]nonane-3-carboxylic acid tert-butyl ester as the common late-stage intermediate. The 9-oxabispidines synthesized were evaluated as the chiral ligands in the Pd(II)-catalyzed oxidative kinetic resolution of secondary alcohols giving good to excellent selectivity factors of up to 19.