110048-17-4

Basic information

• Product Name: 3',4,4',5'-tetramethoxychalcone
• Synonyms: 3',4,4',5'-tetramethoxychalcone
• CAS NO: 110048-17-4
• Molecular Weight: 328.365
• Mol File: 110048-17-4.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: 3',4,4',5'-tetramethoxychalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4,4',5'-tetramethoxychalcone(110048-17-4)
• EPA Substance Registry System: 3',4,4',5'-tetramethoxychalcone(110048-17-4)

Safety Data

• Hazardous Substances Data: 110048-17-4(Hazardous Substances Data)

Upstream product

• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 123-11-5 4-methoxy-benzaldehyde 
• 7478-67-3 (3,4,5-trimethoxy-benzoyl)-malonic acid diethyl ester 
• 637-69-4 4-Methoxystyrene 
• 25245-29-8 5-iodo-1,2,3-trimethoxybenzene 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 

Downstream Products

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 205366-78-5 2-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethane-1-one 
• 1224938-31-1 4-(4-methoxyphenyl)-6-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrimidine-2(1H)-thione 
• 1202071-95-1 3-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)propan-1-ol 
• 500308-92-9 3-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)propan-1-one 
• 1224606-11-4 1-methyl-3-(3',4',5'-trimethoxyphenyl)-5-(4''-methoxyphenyl)-4,5-dihydro-1H-pyrazole 
• 1202071-96-2 (E)-3-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-ol 
• 173542-78-4 [[1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)carbonyl-κO]ethenyl-κC(1)]tetracarbonylmanganese 
• 851729-15-2 [3-(4-methoxy-phenyl)-oxiranyl]-(3,4,5-trimethoxy-phenyl)-methanone 

Relevant articles and documents

Synthesis and evaluation of chalcone derivatives as novel sunscreen agent

Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the research to develop sunscreen agent has been increasing. Chalcone is a promising compound to be developed as its chromophore absorbs in the UV region. Therefore, in

Design and multi-step synthesis of chalcone-polyamine conjugates as potent antiproliferative agents

The aim of this study is to synthesize chalcone-polyamine conjugates in order to enhance bioavailability and selectivity of chalcone core towards cancer cells, using polyamine-based vectors. 3-hydroxy-3′,4,4′,5′-tetramethoxychalcone (1) and 3′,4,4′,5′-tet

Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies

Novel 3-aroyl-1,4-diarylpyrrole derivatives were synthesized to explore structure-activity relationships at the phenyls at positions 1 and 4 of the pyrrole. The presence of amino phenyl rings at positions 1 and 4 of the pyrrole ring were found to be a crucial requirement for potent antitumor activity. Several compounds strongly inhibited tubulin assembly through binding to the colchicine site. Compounds 42, 44, 48, 62 and 69 showed antitumor activity with low nanomolar IC50 values in several cancer cell lines. Compound 48 was generally more effective as an inhibitor of glioblastoma, colorectal and urinary bladder cancer cell lines; 69 consistently inhibited CML cell lines and demonstrated superiority in nilotinib and imatinib resistant LAMA84-R and KBM5-T315I cells. In animal models, compound 48 exhibited significant inhibition of the growth of T24 bladder carcinoma and ES-2 ovarian clear cell carcinoma tumors. Compounds 48 and 69 represent robust lead compounds for the design of new broad-spectrum anticancer agents active in different types of solid and hematological tumors.