11006-31-8 Usage
Description
Monazomycin is a macrocyclic polyol lactone antibiotic that is isolated from several species of Streptoverticillium. It was first reported in 1963 and is known for its activity against Gram-positive bacteria, with weak activity against Gram-negative bacteria. Monazomycin is an important bioprobe for understanding membrane channels due to its ability to induce channel formation when adsorbed onto a lipid bilayer.
Uses
Used in Pharmaceutical Industry:
Monazomycin is used as an antibiotic for its antimicrobial properties, particularly against Gram-positive bacteria. Its ability to induce channel formation in lipid bilayers makes it a valuable tool for studying membrane channels and their role in bacterial resistance.
Used in Research Applications:
Monazomycin is used as a bioprobe in scientific research to investigate the structure and function of membrane channels. This helps researchers to better understand the mechanisms of action of various antibiotics and develop new strategies for combating bacterial resistance.
Biological Activity
monazomycin is a positively charged and polyenelike antibiotic produced by streptomyces [1].monazomycin is able to induce a voltage-dependent conductance in lipid bilayer membranes. monazomycin is selective for monovalent cations and can alter the membrane conductance when applied to one or both sides of the membrane [1]. application of micromolar amounts of monazomycin on one side of phospholipid bilayer membranes induced dramatic voltage-dependent conductance effects. the steady-state conductance was proportional to the 5th power of the monazomycin concentration and increased exponentially with positive voltage (monazomycin side positive); there was an e-fold change in conductance per 4–6 mv. the major current-carrying ions were univalent cations. monazomycin monomers cooperated to form a multimolecular conductance channel. the voltage control of conductance arose from the electric field driving monazomycin molecules at the membrane surface into the membrane and thus affecting the number of channels that were formed [2].
references
[1] bamberg e, janko k. single channel conductance at lipid bilayer membranes in presence of monazomycin[j]. biochimica et biophysica acta (bba)-biomembranes, 1976, 426(3): 447-450.[2] muller r u, finkelstein a. voltage-dependent conductance induced in thin lipid membranes by monazomycin[j]. the journal of general physiology, 1972, 60(3): 263-284.
Check Digit Verification of cas no
The CAS Registry Mumber 11006-31-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,0 and 6 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 11006-31:
(7*1)+(6*1)+(5*0)+(4*0)+(3*6)+(2*3)+(1*1)=38
38 % 10 = 8
So 11006-31-8 is a valid CAS Registry Number.
InChI:InChI=1/C72H133NO22/c1-39-22-19-20-25-55(79)46(8)54(78)24-17-15-18-26-62(84)95-71(42(4)23-16-13-14-21-31-73)50(12)59(83)37-53(77)36-58(82)48(10)66(88)47(9)56(80)34-51(75)29-27-40(2)63(85)41(3)28-30-52(76)35-57(81)49(11)67(89)60(33-45(7)65(87)44(6)32-43(5)64(39)86)93-72-70(92)69(91)68(90)61(38-74)94-72/h19,22,28,30,32-33,39-42,44,46-61,63-72,74-83,85-92H,13-18,20-21,23-27,29,31,34-38,73H2,1-12H3/b22-19-,30-28-,43-32-,45-33-/t39?,40?,41?,42?,44?,46?,47?,48?,49?,50?,51?,52?,53?,54?,55?,56?,57?,58?,59?,60?,61-,63?,64?,65?,66?,67?,68-,69+,70+,71?,72+/m1/s1
