1101109-32-3

Basic information

• Product Name: 2-amino-5-cyano-4-methoxybenzoic acid
• Synonyms: 2-amino-5-cyano-4-methoxybenzoic acid
• CAS NO: 1101109-32-3
• Molecular Weight: 192.174
• Mol File: 1101109-32-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-amino-5-cyano-4-methoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-cyano-4-methoxybenzoic acid(1101109-32-3)
• EPA Substance Registry System: 2-amino-5-cyano-4-methoxybenzoic acid(1101109-32-3)

Safety Data

• Hazardous Substances Data: 1101109-32-3(Hazardous Substances Data)

Upstream product

• 143945-65-7 2-amino-4-fluoro-5-bromobenzoic acid 
• 67-56-1 methanol 
• 7251-09-4 4-amino-2-methoxybenzonitrile 

Downstream Products

• 398487-31-5 4-chloro-7-methoxyquinoline-6-carbonitrile 

Relevant articles and documents

ARYLCARBOXAMIDES AND USES THEREOF

The present disclosure is directed to compounds of formula (I): or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof. Compounds of formula (I) are inhibitors of NOX4 and are useful in the treatment of fibrotic diseases such as scleroderma; lung disease, such as pulmonary fibrosis including idiopathic pulmonary fibrosis (IPF); heart disease, such as heart failure due to ischaemic heart disease, valvular heart disease and hypertensive heart disease, diabetic cardiomyopathy and hypertension; liver disease, such as cirrhosis of the liver; and kidney disease, such as progressive kidney disease glomerulonephritis and diabetic nephropathy; and eye disease such as diabetic retinopathy; skin or subcutaneous scarring, such as keloids, adhesions, hypertrophic scarring or cosmetic scarring; or as an adjuvant or anti-fibrotic in pancreatic cancer to increase chemotherapeutic drug penetration by reducing the density of the connective tissue stroma.