11032-79-4

Basic information

• Product Name: ALPHA-BUNGAROTOXIN
• Synonyms: ALPHA-BUNGAROTOXIN;ALPHA-BUNGAROTOXIN, BUNGARUS MULTICINCTUS;ALPHA-BUTX;ALPHA-BGT;A-BUNGAROTOXIN;H-ILE-VAL-CYS-HIS-THR-THR-ALA-THR-SER-PRO-ILE-SER-ALA-VAL-THR-CYS-PRO-PRO-GLY-GLU-ASN-LEU-CYS-TYR-ARG-LYS-MET-TRP-CYS-ASP-ALA-PHE-CYS-SER-SER-ARG-GLY-LYS-VAL-VAL-GLU-LEU-GLY-CYS-ALA-ALA-THR-CYS-PRO-SER-LYS-LYS-PRO-TYR-GLU-GLU-VAL-THR-CYS-CYS-SER-THR-ASP-LYS-CYS-ASN-PRO-HIS-PRO-LYS-GLN-ARG-PRO-GLY-OH;BUNGARUS MULTICINCTUS TOXIN, ALPHA;A-BUNGAROTOXIN FROM THE VENOM OF THE
• CAS NO: 11032-79-4
• Molecular Formula: C50H70O14
• Molecular Weight: 895.0824
• EINECS: 234-266-6
• Product Categories: Acetylcholine receptor
• Mol File: 11032-79-4.mol
• Article Data: 0

Chemical Properties

• Appearance: white/solid
• Storage Temp.: −20°C
• CAS DataBase Reference: ALPHA-BUNGAROTOXIN(CAS DataBase Reference)
• NIST Chemistry Reference: ALPHA-BUNGAROTOXIN(11032-79-4)
• EPA Substance Registry System: ALPHA-BUNGAROTOXIN(11032-79-4)

Safety Data

• WGK Germany: 3
• RTECS: QQ4495249
• Hazardous Substances Data: 11032-79-4(Hazardous Substances Data)

Usage

Description

ALPHA-BUNGAROTOXIN is a protein that binds specifically to acetylcholine receptors. It blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor and prevents the opening of nicotinic receptor-associated ion channels. It is highly specific for the α7-subtype of neuronal nAChR and has a molecular weight of 8000.

Uses

Used in Neurobiological Research:
ALPHA-BUNGAROTOXIN is used as a research tool for studying the function and mechanism of acetylcholine receptors, particularly the α7-subtype. It helps in understanding the role of these receptors in neuronal signaling and synaptic transmission.
Used in Drug Development:
ALPHA-BUNGAROTOXIN can be used in the development of drugs targeting acetylcholine receptors, particularly for conditions related to neuromuscular disorders and cognitive functions. Its high specificity for the α7-subtype makes it a valuable tool in the discovery and optimization of potential therapeutic agents.
Used in Toxicological Studies:
Due to its irreversible binding to acetylcholine receptors, ALPHA-BUNGAROTOXIN can be used in toxicological studies to investigate the effects of neurotoxins on the nervous system and develop potential antidotes or treatments for toxin-induced conditions.

Hazard

Nuerotoxic.

Biochem/physiol Actions

Product does not compete with ATP.