110366-36-4Relevant articles and documents
An Efficient Biogenetic-Type Transformation of 3-Tertiary-hydroxyalkanoic Acids to Olefinic Compounds
Ohta, Shunsaku,Nozaki, Akira,Ohashi, Norihiko,Nishimura, Yuko,Yoneda, Yumiko,Okamoto, Masao
, p. 5144 - 5148 (2007/10/02)
The readily available 3-tertiary-hydroxyalkanoic acids (3) could be smoothly converted to the olefinic compounds (5) by dehydrative decarboxylation, by treatment with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline.This efficient reaction mimics the olefination at the initial stage of the so-called "mevalonic acid route".Keywords-olefination; biogenetic-type synthesis; β-hydroxyalkanoic acid; mevalonic acid route; dehydrative decarboxylation; β-propiolactone; mixed anhydride; acyl activation; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; 1-acyl-1H-imidazole