1104202-25-6Relevant articles and documents
First Cdc7 kinase inhibitors: Pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery
Menichincheri, Maria,Bargiotti, Alberto,Berthelsen, Jens,Bertrand, Jay A.,Bossi, Roberto,Ciavolella, Antonella,Cirla, Alessandra,Cristiani, Cinzia,Croci, Valter,D'Alessio, Roberto,Fasolini, Marina,Fiorentini, Francesco,Forte, Barbara,Isacchi, Antonella,Martina, Katia,Molinari, Antonio,Montagnoli, Alessia,Orsini, Paolo,Orzi, Fabrizio,Pesenti, Enrico,Pezzetta, Daniele,Pillan, Antonio,Poggesi, Italo,Roletto, Fulvia,Scolaro, Alessandra,Tato, Marco,Tibolla, Marcellino,Valsasina, Barbara,Varasi, Mario,Volpi, Daniele,Santocanale, Corrado,Vanotti, Ermes
body text, p. 293 - 307 (2009/10/09)
Cdc7 kinase is a key regulator of the S-phase of the cell cycle, known to promote the activation of DNA replication origins in eukaryotic organisms. Cdc7 inhibition can cause tumor-cell death in a p53-independent manner, supporting the rationale for devel
