1104461-51-9Relevant articles and documents
Phenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship
Macsari, Istvan,Sandberg, Lars,Besidski, Yevgeni,Gravenfors, Ylva,Ginman, Tobias,Bylund, Johan,Bueters, Tjerk,Eriksson, Anders B.,Lund, Per-Eric,Venyike, Elisabet,Arvidsson, Per I.
scheme or table, p. 3871 - 3876 (2011/08/06)
Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Phenyl isoxazole carbamate 1 was identified as a potent and selective NaV1.7 blocker. Structural analogues of 1, both carbamates,