110457-29-9

Basic information

• Product Name: (S)-2-hydroxymethyl-N-((R)-2-hydroxy-2-phenyl)propanoylpyrrolidine
• Synonyms: (S)-2-hydroxymethyl-N-((R)-2-hydroxy-2-phenyl)propanoylpyrrolidine
• CAS NO: 110457-29-9
• Molecular Weight: 249.31
• Mol File: 110457-29-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-hydroxymethyl-N-((R)-2-hydroxy-2-phenyl)propanoylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-hydroxymethyl-N-((R)-2-hydroxy-2-phenyl)propanoylpyrrolidine(110457-29-9)
• EPA Substance Registry System: (S)-2-hydroxymethyl-N-((R)-2-hydroxy-2-phenyl)propanoylpyrrolidine(110457-29-9)

Safety Data

• Hazardous Substances Data: 110457-29-9(Hazardous Substances Data)

Upstream product

• 25145-43-1 2-phenylpropionyl chloride 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 219598-57-9 (S)-2-hydroxymethyl-N,O-bisbenzoylformyl pyrrolidine 
• 75-16-1 methylmagnesium bromide 
• 219598-58-0 (S)-2-hydroxymethyl-N-benzoylformyl pyrrolidine 
• 110457-27-7 1-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-2-phenyl-propan-1-one 

Downstream Products

• 3966-30-1 (R)-Atrolactic acid 

Relevant articles and documents

Asymmetric reactions of α-ketoacid-derived hemiacetals: Stereoselective synthesis of α-hydroxy acids

N-Acylation of prolinol with α-ketoacid chlorides results in concomitant hemiacetalization of the α-keto amide by the prolinol hydroxyl group. (R) or (S) α-hydroxy acids are obtained with good enantiomeric excess by stereodivergent reduction of these hemiacetals. Reaction with Grignard reagents at ambient temperature furnishes (R) α-alkyl mandelic acids with good stereoselectivity.