110466-45-0

Basic information

• Product Name: 2-hydroxy-2,3,3-trimethyl-5-phenyl-3,4-dihydro-2 H-pyrrole
• CAS NO: 110466-45-0
• Molecular Weight: 203.284
• Mol File: 110466-45-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-2,3,3-trimethyl-5-phenyl-3,4-dihydro-2 H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-2,3,3-trimethyl-5-phenyl-3,4-dihydro-2 H-pyrrole(110466-45-0)
• EPA Substance Registry System: 2-hydroxy-2,3,3-trimethyl-5-phenyl-3,4-dihydro-2 H-pyrrole(110466-45-0)

Safety Data

• Hazardous Substances Data: 110466-45-0(Hazardous Substances Data)

Upstream product

• 110466-43-8 3,3-dimethyl-1-phenylpentane-1,4-dione 
• 5650-07-7 3-methyl-1-phenyl-but-2-en-1-one 
• 128259-95-0 3,3-dimethyl-4-nitro-1-phenyl-pentan-1-one 
• 128260-03-7 4,4-ethylenedioxy-2-methyl-4-phenylbutan-2-ol 

Relevant articles and documents

Synthesis and Chemistry of Azolenines. Part 16. Preparation of both 3H- and 2H-Pyrroles from 2,2-Disubstituted 1,4-Diketones via the Paal-Knorr Reaction, and Isolation of Intermediate 2-Hydroxy-3,4-dihydro-2H-pyrroles

Treatment of 2,2-disubstituted 1,4-diketones (1) with liquid ammonia gives high yields of isolable isomeric 2-hydroxy-3,4-dihydro-2H-pyrroles (10) and (11), many of which may be dehydrated to 3H-pyrroles (2) together, in certain cases, with isomeric methylene-pyrrolines (14) and (15).When heated in acetic acid with ammonium acetate, the diketones (1) yield 2H-pyrroles (18), sometimes in admixture with 3H-pyrroles (2) from which they are formed by rearrangement.The diketones (1), including some novel examples, are prepared from nitro-ketones (6) by the Nef reaction, as well as other methods.