1104808-65-2

Basic information

• Product Name: N-{2-iodo-4-[(1H-1,2,4-triazol-1-yl)methyl]phenyl}acetamide
• CAS NO: 1104808-65-2
• Molecular Weight: 342.139
• Mol File: 1104808-65-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-{2-iodo-4-[(1H-1,2,4-triazol-1-yl)methyl]phenyl}acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{2-iodo-4-[(1H-1,2,4-triazol-1-yl)methyl]phenyl}acetamide(1104808-65-2)
• EPA Substance Registry System: N-{2-iodo-4-[(1H-1,2,4-triazol-1-yl)methyl]phenyl}acetamide(1104808-65-2)

Safety Data

• Hazardous Substances Data: 1104808-65-2(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 160194-26-3 4-((1H-1,2,4-triazol-1-yl)methyl)-2-iodobenzenamine 

Relevant articles and documents

A new synthesis of rizatriptan based on radical cyclization

A new methodology useful for preparation of indole derivatives bearing a 2-(dialkylamino)-ethyl substituent at the 3-position has been developed. Application of this methodology to the synthesis of N,N-dimethyl-2-{5-[(1H-1,2, 4-triazol-1-yl)methyl]-1H-indol-3-yl}ethan-1-amine (rizatriptan; 3) is described. The key reaction step is based on the radical cyclization of N-[4-(dimethylamino)but-2-yn-1-yl]-N-(2-iodo-4-[(1H-1,2,4-triazol-1-yl)methyl] phenyl}-acetamide (21), easily available by the Mannich reaction, and subsequent isomerization of the primarily formed methylidene derivative 22.