110548-05-5

Basic information

• Product Name: (+)-ethyl 1,4-dihydro-1-<1(R)-(hydroxymethyl)ethyl>-4-oxo-6,7,8-trifluoroquinoline-3-carboxylate
• CAS NO: 110548-05-5
• Molecular Weight: 329.276
• Mol File: 110548-05-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+)-ethyl 1,4-dihydro-1-<1(R)-(hydroxymethyl)ethyl>-4-oxo-6,7,8-trifluoroquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-ethyl 1,4-dihydro-1-<1(R)-(hydroxymethyl)ethyl>-4-oxo-6,7,8-trifluoroquinoline-3-carboxylate(110548-05-5)
• EPA Substance Registry System: (+)-ethyl 1,4-dihydro-1-<1(R)-(hydroxymethyl)ethyl>-4-oxo-6,7,8-trifluoroquinoline-3-carboxylate(110548-05-5)

Safety Data

• Hazardous Substances Data: 110548-05-5(Hazardous Substances Data)

Upstream product

• 110548-04-4 (-)-ethyl 2-<<<(R)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate 

Downstream Products

• 110548-07-7 (+)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylic acid 
• 100986-86-5 (R)-ofloxacin 

Relevant articles and documents

Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-py ido[1,2,3,-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin)

A short and efficient synthesis, starting with (R)- and (S)-alaninol, of the two optical antipodes of the quinolone antimicrobial agent ofloxacin has been devised. Testing in vitro of the products against a range of bacteria and in an assay system incorporating purified DNA gyrase from different bacterial species demonstrates that the S-(-) enantiomer is substantially the more active.