1105662-87-0 Usage
Description
1-Boc-3-methoxycarbonylme..., also known as tert-Butyl 3-(2-methoxy-2-oxoethylidene)azetidine-1-carboxylate, is a chemical compound that serves as a valuable intermediate in the synthesis of various complex molecules. It is characterized by its unique structure, which includes a Boc-protected azetidine ring and a methoxycarbonyl group, making it a versatile building block in the field of medicinal chemistry.
Uses
Used in Medicinal Chemistry:
1-Boc-3-methoxycarbonylme... is used as a key intermediate for the preparation of spirocyclic β-proline esters, which are essential building blocks in the development of novel pharmaceutical compounds. These spirocyclic β-proline esters are known to possess diverse biological activities and are often found in the core structures of various bioactive molecules, making them valuable for the design and synthesis of new drugs.
In the pharmaceutical industry, 1-Boc-3-methoxycarbonylme... is used as a synthetic precursor for the development of innovative therapeutic agents targeting a wide range of diseases and conditions. The compound's unique structure allows for the creation of complex molecular architectures that can be tailored to interact with specific biological targets, such as enzymes, receptors, or ion channels, with high selectivity and potency.
Furthermore, the use of 1-Boc-3-methoxycarbonylme... in medicinal chemistry enables researchers to explore new avenues in drug discovery, potentially leading to the development of more effective and safer treatments for various medical conditions. By leveraging the compound's unique properties, chemists can design and synthesize novel drug candidates with improved pharmacokinetic and pharmacodynamic profiles, ultimately contributing to the advancement of healthcare and the well-being of patients worldwide.
Check Digit Verification of cas no
The CAS Registry Mumber 1105662-87-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,0,5,6,6 and 2 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1105662-87:
(9*1)+(8*1)+(7*0)+(6*5)+(5*6)+(4*6)+(3*2)+(2*8)+(1*7)=130
130 % 10 = 0
So 1105662-87-0 is a valid CAS Registry Number.
1105662-87-0Relevant articles and documents
Synthesis of oxetane/azetidine containing spirocycles
Hamill, Rosalie,Jones, Benjamin,Pask, Christopher M.,Sridharan, Visuvanathar
, p. 1126 - 1129 (2019)
Oxetane-benzopyran spirocycles were synthesised via a palladium catalysed cyclisation-cross coupling cascade reaction whilst oxetane/azetidine-pyrrolidino isoindolone spirocycles were synthesised via a silver catalysed 1,3-dipolar cycloaddition reaction f
Rhodium catalyzed C-C bond cleavage/coupling of 2-(azetidin-3-ylidene)acetates and analogs
Yang, Xuan,Kong, Wei-Yu,Gao, Jia-Ni,Cheng, Li,Li, Nan-Nan,Li, Meng,Li, Hui-Ting,Fan, Jun,Gao, Jin-Ming,Ouyang, Qin,Xie, Jian-Bo
supporting information, p. 12707 - 12710 (2019/10/28)
The C-C bond cleavage/coupling of 2-(azetidin-3-ylidene)acetates with aryl boronic acids catalyzed by a rhodium complex was studied with a "conjugate addition/β-C cleavage/protonation" strategy.
Furo-3-carboxamide derivatives and methods of use
-
Page/Page column 101; 102, (2017/10/24)
Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, Z1, Z2, and n are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
