110590-60-8

Basic information

• Product Name: CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG
• Synonyms: H-CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG-OH;LAMININ FRAGMENT 925-933;LAMININ NONAPEPTIDE;LAMININ B1 CHAIN FRAGMENT (925-933);CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG;CDPGYIGSR;cys-ser-arg-ala-arg-lys-gln-ala-ala-*ser-ile-lys-;Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg (1)
• CAS NO: 110590-60-8
• Molecular Formula: C40H62N12O14S
• Molecular Weight: 967.06
• EINECS: 202-005-5
• Product Categories: Neuroscience
• Mol File: 110590-60-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.54±0.1 g/cm3(Predicted)
• Storage Temp.: −20°C
• Solubility: Soluble in 5% acetic acid.
• PKA: 3.23±0.10(Predicted)
• CAS DataBase Reference: CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG(CAS DataBase Reference)
• NIST Chemistry Reference: CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG(110590-60-8)
• EPA Substance Registry System: CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG(110590-60-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 110590-60-8(Hazardous Substances Data)

Usage

Description

CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG is a peptide derived from human laminin B1, specifically from the residues 925-933. It has the ability to bind the laminin receptor and is known for its role in inhibiting experimental metastasis. This peptide is a promising candidate for various product applications in the field of medical research and diagnostics.

Uses

Used in Cancer Research:
CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG is used as a research tool for cancer studies, particularly in the context of metastasis inhibition. Its interaction with the laminin receptor makes it a valuable asset in understanding the mechanisms behind cancer progression and the development of potential therapeutic strategies.
Used in Western Blot:
In the field of molecular biology, CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG is used as a blocking peptide in Western Blot analysis. It helps prevent non-specific binding of antibodies to the membrane, ensuring accurate and reliable results.
Used in Immunohistochemistry:
CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG is employed as a blocking peptide in immunohistochemistry, a technique used to visualize the distribution of specific proteins within tissue sections. It aids in reducing background noise and enhancing the specificity of the staining process.
Used in Immunofluorescence:
This peptide is also used in immunofluorescence, a technique that involves the use of fluorescently labeled antibodies to detect and locate specific proteins within cells or tissue sections. CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG serves as a blocking peptide to minimize non-specific binding and improve the accuracy of the results.
Used in Cell Culture:
CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG is utilized in cell culture applications, where it can be used to study the effects of the peptide on cell adhesion, migration, and proliferation, as well as its potential role in modulating cellular interactions with the extracellular matrix.
Used in Flow Cytometry:
In flow cytometry, a technique used to analyze and sort cells based on their physical and chemical properties, CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG can be employed as a reagent to investigate the expression of the laminin receptor on the cell surface and its potential role in cellular processes.
Used in Diagnostics:
CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG has potential applications in the development of diagnostic tools and assays, particularly for detecting the presence of the laminin receptor or monitoring its activity in various disease states, including cancer.
Used in Drug Development:
The peptide may also be useful in the development of new drugs targeting the laminin receptor or related pathways, with potential applications in cancer therapy and other diseases where the laminin receptor plays a significant role.

Biological Activity

laminin (925-933) is a peptide(cys-asp-pro-gly-tyr-ile-gly-ser-arg) derived from residues 925-933 of the laminin b1 chain that binds to the laminin receptor.laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. they have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly a, b1, and b2, respectively)the laminin beta 1 chain has 7 structurally distinct domains, which it shares with other beta chain isomers. laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from engelbreth-holm-swarm (ehs) tumor. a sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.figure1 structure of lamininfigure2 formula of lamininb1 (925-933)

references

1.Ikonen J, Pikkarainen T, Savolainen ER, Tryggvason K (Feb 1989). "A Hpa I polymorphism in the human laminin B1 chain gene on 7q22". Nucleic Acids Res 17 (1): 473.2.Roche KB, Moore JW, Surana RB, Wilson BE (May 1989). "Aortic root dilatation associated with partial trisomy 7(q31.2----qter)". Pediatr Cardiol 10 (1): 53–5.3.Bonneau D, Huret JL, Godeau G, Couet D, Putterman M, Tanzer J, Babin P, Larregue M (Sep 1991). "Recurrent ctb(7)(q31.3) and possible laminin involvement in a neonatal cutis laxa with a Marfan phenotype". Hum Genet 87 (3): 317–9.