110661-91-1

Basic information

• Product Name: T-BUTYL 4-BROMOBUTYRATE
• Synonyms: Butanoic acid, 4-broMo-,1,1-diMethylethyl ester;tert-Butyl 4-bromobutanoate, tech;tert-Butyl4-bromobutanoate95%;4-Bromobutanoic acid tert-butyl ester
• CAS NO: 110661-91-1
• Molecular Formula: C₈H₁₅BrO₂
• Molecular Weight: 223.12
• Product Categories: Acids & Esters;Bromine Compounds
• Mol File: 110661-91-1.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 225.9 °C at 760 mmHg
• Flash Point: 117.1 °C
• Appearance: /
• Density: 1.258 g/cm³
• Vapor Pressure: 0.0843mmHg at 25°C
• Refractive Index: 1.46
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: T-BUTYL 4-BROMOBUTYRATE(CAS DataBase Reference)
• NIST Chemistry Reference: T-BUTYL 4-BROMOBUTYRATE(110661-91-1)
• EPA Substance Registry System: T-BUTYL 4-BROMOBUTYRATE(110661-91-1)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: 34-36/37/38
• Safety Statements: 22-26-36/37/39-45
• RIDADR: 1760
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 110661-91-1(Hazardous Substances Data)

Usage

Description

T-BUTYL 4-BROMOBUTYRATE, also known as t-butyl 4-bromocrotonate, is an organic compound with the chemical formula C8H13BrO2. It is a potent CB1 receptor antagonist, which plays a significant role in the cannabinoid-1 receptor signaling process. T-BUTYL 4-BROMOBUTYRATE has been found to inhibit feeding behaviors and possesses anti-inflammatory properties, making it a promising candidate for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
T-BUTYL 4-BROMOBUTYRATE is used as a pharmaceutical agent for its ability to inhibit the CB1 receptor, which is involved in regulating feeding behaviors. By blocking this receptor, it can help in the development of treatments for obesity and other related conditions.
Used in Research and Development:
T-BUTYL 4-BROMOBUTYRATE is used as a research compound for studying the role of CB1 receptors in various physiological processes. This can lead to a better understanding of the endocannabinoid system and the development of new therapeutic strategies for a range of conditions.
Used in Anti-inflammatory Applications:
T-BUTYL 4-BROMOBUTYRATE is used as an anti-inflammatory agent due to its ability to modulate the immune system and reduce inflammation. This property makes it a potential candidate for the development of treatments for various inflammatory diseases, such as arthritis, asthma, and inflammatory bowel disease.
Used in Drug Delivery Systems:
In the field of drug delivery, T-BUTYL 4-BROMOBUTYRATE can be used as a component in the development of novel drug delivery systems. Its properties as a CB1 receptor antagonist can be leveraged to improve the targeting and efficacy of drugs, particularly in the treatment of obesity and related conditions.

InChI:InChI=1/C8H15BrO2/c1-8(2,3)11-7(10)5-4-6-9/h4-6H2,1-3H3

Upstream product

• 2623-87-2 bromobutyric acid 
• 75-65-0 tert-butyl alcohol 
• 115-11-7 isobutene 
• 59854-12-5 tert-butyl 4-hydroxybutyrate 
• 927-58-2 4-bromobutyroyl chloride 
• 865-47-4 potassium tert-butylate 
• 15026-17-2 succinic acid mono-tert-butyl ester 

Downstream Products

• 145351-42-4 N¹,N⁸-Bis(p-methoxytrityl) N⁴-(tert-butyloxycarbonylpropyl) spermidine 
• 157465-55-9 1,1-dimethylethyl 4-<<<4-(2,2-dimethyl-1-oxopropyl)benzoyl>amino>oxy>butanoate 
• 220658-25-3 t-butyl 4-(2-iodophenyloxy)butyrate 
• 252940-43-5 Boc-NH-CH((CH₂)3NHZ)-CH₂-S-(CH₂)3COOtBu 
• 252940-44-6 4-(5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentylsulfanyl)-butyric acid tert-butyl ester 
• 252940-42-4 4-(6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexylsulfanyl)-butyric acid tert-butyl ester 
• 398142-87-5 (+/-)-1-acetoxy-1-[3-(4-carbotertbutyloxy)-1-butyloxy-5-methoxyphenyl]-2-phenyl-2-(1,3-dithian-2-yl)ethane 
• 874210-33-0 4,6-bis[3-(tert-butoxycarbonyl)propoxy]isophthalic acid dimethyl ester 
• 874210-16-9 2,4-bis[3-(tert-butoxycarbonyl)propoxy]-5-nitrobenzoic acid methyl ester 
• 1002566-64-4 tert-butyl 4-(3,3-diphenylpropylamino)butanoate 
• 958257-24-4 tert-butyl 4-phenethoxybutanoate 

Relevant articles and documents

DNA-templated synthesis of trimethine cyanine dyes: A versatile fluorogenic Reaction for sensing G-quadruplex formation

(Figure Presented) A healthy glow: Fluorogenic peptide nucleic acids (PNAs) functionalized with indoline derivatives are used to specifically sense G-quadruplex formation. Upon hybridization of both PNAs to the singlestranded flanking arms of quadruplex DNA (see scheme), the synthesis of a trimethine cyanine dye is templated. Dye formation can be detected by the appearance of a characteristic fluorescence signal.

Design and synthesis of triphenylphosphonium-porphyrin@xylan nanoparticles for anticancer photodynamic therapy

Most photosensitizers (PS) suffer from a lack of water solubility and from a low selectivity toward tumor cells. Delivery systems using nanoparticles make it possible to improve PS water solubility, and also tumor targeting via the enhanced permeability a

Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging

Single-molecule localization microscopy (SMLM) allows the reconstruction of super-resolution images but generally requires prior intense laser irradiation and in some cases additives to induce blinking of conventional fluorophores. We previously introduced a spontaneously blinking rhodamine fluorophore based on an intramolecular spirocyclization reaction for live-cell SMLM under physiological conditions. Here, we report a novel principle of spontaneous blinking in living cells, which utilizes reversible ground-state nucleophilic attack of intracellular glutathione (GSH) upon a xanthene fluorophore. Structural optimization afforded two pyronine fluorophores with different colors, both of which exhibit equilibrium (between the fluorescent dissociated form and the nonfluorescent GSH adduct form) and blinking kinetics that enable SMLM of microtubules or mitochondria in living cells. Furthermore, by using spontaneously blinking fluorophores working in the near-infrared (NIR) and green ranges, we succeeded in dual-color live-cell SMLM without the need for optimization of the imaging medium.

Control of conformation in α-helix mimicking aromatic oligoamide foldamers through interactions between adjacent side-chains

The design, synthesis and structural characterization of non-natural oligomers that adopt well-defined conformations, so called foldamers, is a key objective in developing biomimetic 3D functional architectures. For the aromatic oligoamide foldamer family