110674-90-3Relevant articles and documents
AN APPROACH TO NOVEL ELLIPTICINE GLYCOSIDES
Langendoen, Albert,Koomen, Gerrit-Jan,Pandit, Upendra K.
, p. 3627 - 3632 (2007/10/02)
Reactions of 6-methylellipticine (3a) with the aim of preparing various functionalized derivatives have been studied.A base-(LDA) mediated reaction of 3a with formaldehyde results in a C(11)-hydroxyethyl derivative (3d), which has been coupled with ribose-, glucose- and galactose derivatives to give, after deprotection, novel ellipticine glycosides 3e-g.The sequene of reactions constitute a new strategy for the synthesis of a wide range of ellipticine derivatives with improved solubility characteristics.