110683-52-8

Basic information

• Product Name: 2-Propenamide, 3-(4-butylphenyl)-N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-
• CAS NO: 110683-52-8
• Molecular Formula: C23H21N5O3
• Molecular Weight: 415.451
• Mol File: 110683-52-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propenamide, 3-(4-butylphenyl)-N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide, 3-(4-butylphenyl)-N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-(110683-52-8)
• EPA Substance Registry System: 2-Propenamide, 3-(4-butylphenyl)-N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-(110683-52-8)

Safety Data

• Hazardous Substances Data: 110683-52-8(Hazardous Substances Data)

Upstream product

• 62718-62-1 (E)-3-(4-n-butylphenyl)acrylic acid 
• 110683-22-2 8-amino-4-oxo-2-(5-1H-tetrazolyl)-4H-1-benzopyran 
• 1200-14-2 4-(n-butyl)benzaldehyde 
• 104-51-8 1-butylbenzene 

Relevant articles and documents

New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships

(p-Amylcinnamoyl)anthranilic acid (3a) had moderate antagonist activities against LTD4-induced smooth muscle contraction on guinea pig ileum and LTC4-induced bronchoconstriction in anesthetized guinea pigs. Modifications were made in the hydrophobic part (cinnamoyl moiety) and the hydrophilic part (anthranilate moiety) of 3a. A series of 8-(benzoylamino)-2-tetrazol-5-yl-1,4-benzodioxans and 8-(benzoylamino)-2-tetrazol-5-yl-4-oxo-4H-1-benzopyrans were revealed to be potent antagonists of leukotrienes C4 and D4. Among both series, ONO-RS-347 (18k) and ONO-RS411 (19h) were the most potent and orally active antagonists, respectively. Structure-activity relationships are discussed.