110700-77-1

Basic information

• Product Name: 6-Chloromethyl-2-(4-nitro-phenyl)-1H-pyrimidin-4-one
• CAS NO: 110700-77-1
• Molecular Weight: 265.656
• Mol File: 110700-77-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-Chloromethyl-2-(4-nitro-phenyl)-1H-pyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloromethyl-2-(4-nitro-phenyl)-1H-pyrimidin-4-one(110700-77-1)
• EPA Substance Registry System: 6-Chloromethyl-2-(4-nitro-phenyl)-1H-pyrimidin-4-one(110700-77-1)

Safety Data

• Hazardous Substances Data: 110700-77-1(Hazardous Substances Data)

Upstream product

• 41658-12-2 Chlortetrolsaeuremethylester 
• 15723-90-7 4-nitrobenzamidine hydrochloride 

Relevant articles and documents

Chloromethyl Substituted Heterocycles from Methyl Chlorotetrolate

Reaction of amidines, isothioureas or thioureas with methyl chlorotetrolate 1 leads to pyrimidin-4-ones 2 and 1,3-thiazines (3), respectively.Compounds 2 and 3 are starting materials for the synthesis of 6-chloromethyl-uracils (4), 1,3-thiazine-2,4-dione 5 and 6-benzylthiomethyl-thiazinone (6). 2-Aminothiazoles react with the ester 1 to yield 5-chloromethyl-thiazolopyrimidin-7-ones (7).The 5-oxo isomers 8 are obtained by reaction of thiazoles with ethyl γ-chloroacetoacetate.By reaction of 2-mercaptoimidazoles and 1 or chlorotetrolic acid the condensed 1,3-thiazinones (10) result.In the latter case the intermediate 9 is isolated.It can be cyclised to 10 by heating with acetic anhydride and sulphuric acid.