11078-21-0 Usage
Description
FILIPIN COMPLEX is a family of pentaene macrocyclic lactones first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. It consists of four analogues, with filipin III comprising the bulk (>70%) of the complex. FILIPIN COMPLEX is a potent broad-spectrum antifungal agent that also exhibits antitumor and antiviral activities. It acts by binding cell membrane sterols, disrupting membrane integrity.
Uses
Used in Antifungal Applications:
FILIPIN COMPLEX is used as an antifungal agent for its potent broad-spectrum activity against various fungal species.
Used in Antitumor Applications:
FILIPIN COMPLEX is used as an antitumor agent for its ability to exhibit antitumor activities.
Used in Antiviral Applications:
FILIPIN COMPLEX is used as an antiviral agent for its capacity to display antiviral properties.
Used in Cell Biology Research:
FILIPIN COMPLEX from Streptomyces filipinensis is used as a profluorescence probe for detecting free cholesterol in cells, aiding in cell biology research and understanding cholesterol distribution and transport within cellular membranes.
Biochem/physiol Actions
Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability. Filipin binds to model crystalline phase lipid bilayers containing cholesterol, and to liquid phase bilayers with or without cholesterol, in an orientation that forms membrane pores.It both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.
Check Digit Verification of cas no
The CAS Registry Mumber 11078-21-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,7 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 11078-21:
(7*1)+(6*1)+(5*0)+(4*7)+(3*8)+(2*2)+(1*1)=70
70 % 10 = 0
So 11078-21-0 is a valid CAS Registry Number.