1108169-97-6Relevant articles and documents
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases
Tao, Zhi-Fu,Hasvold, Lisa A.,Leverson, Joel D.,Han, Edward K.,Guan, Ran,Johnson, Eric F.,Stoll, Vincent S.,Stewart, Kent D.,Stamper, Geoff,Soni, Nirupama,Bouska, Jennifer J.,Luo, Yan,Sowin, Thomas J.,Lin, Nan-Horng,Giranda, Vincent S.,Rosenberg, Saul H.,Penning, Thomas D.
experimental part, p. 6621 - 6636 (2010/05/02)
Pim-1, Pim-2, and Pim-3 are a family of serine/threonine kinases which have been found to be overexpressed in a variety of hematopoietic malignancies and solid tumors. Benzothienopyrimidinones were discovered as a novel class of Pim inhibitors that potent
