1108184-76-4

Basic information

• Product Name: C₂₅H₂₅ClN₄O₂
• CAS NO: 1108184-76-4
• Molecular Weight: 448.952
• Mol File: 1108184-76-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₅ClN₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₅ClN₄O₂(1108184-76-4)
• EPA Substance Registry System: C₂₅H₂₅ClN₄O₂(1108184-76-4)

Safety Data

• Hazardous Substances Data: 1108184-76-4(Hazardous Substances Data)

Upstream product

• 762287-57-0 (4-chloro-2-methoxyphenyl)boronic acid 
• 1039826-64-6 (1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one-4-trifluoromethanesulfonate 

Relevant articles and documents

Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones as MCH-1 antagonists for the treatment of obesity

A new series of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones possessing MCH-1 receptor antagonism is presented. Suzuki coupling of boronic acids with key triflate 6 allowed rapid generation of a range of analogs. The SAR of the MCH-1 receptor was explored with a variety of aryl and heterocyclic moieties. Selected compounds were studied in a five-day diet induced obese mouse model to evaluate their potential use as weight loss agents.