1108717-22-1Relevant articles and documents
Towards metformin prodrugs
Huttunen, Kristiina M.,Leppaenen, Jukka,Kemppainen, Eeva,Palonen, Piia,Rautio, Jarkko,Jaervinen, Tomi,Vepsaelaeinen, Jouko
experimental part, p. 3619 - 3624 (2009/07/04)
The first examples of possible metformin prodrugs have been synthesized and characterized by spectroscopic methods. These five different types of chemically stable prodrugs were prepared from metformin and the corresponding halogenated promoieties. The products from unstable derivatives were also identified and reasons for the rearrangements are discussed. Georg Thieme Verlag Stuttgart · New York.