1109226-28-9

Basic information

• Product Name: 1-[4-(2-propylthiazol-5-yl)phenyl]propan-1-one
• Synonyms: 1-[4-(2-propylthiazol-5-yl)phenyl]propan-1-one
• CAS NO: 1109226-28-9
• Molecular Weight: 259.372
• Mol File: 1109226-28-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-[4-(2-propylthiazol-5-yl)phenyl]propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(2-propylthiazol-5-yl)phenyl]propan-1-one(1109226-28-9)
• EPA Substance Registry System: 1-[4-(2-propylthiazol-5-yl)phenyl]propan-1-one(1109226-28-9)

Safety Data

• Hazardous Substances Data: 1109226-28-9(Hazardous Substances Data)

Upstream product

• 17626-75-4 2-(n-propyl)-thiazole 
• 10342-83-3 4'-Bromopropiophenone 

Relevant articles and documents

Cyclopentyl methyl ether: An alternative solvent for palladium-catalyzed direct arylation of heteroaromatics

Some ethers, such as cyclopentyl methyl ether and di-n-butyl ether, which can be considered as "greener" solvents than N,N-dimethylacetamide (DMAc) or DMF, can be advantageously employed for the palladium-catalyzed direct arylation of heteroaromatics. In the presence of such ethers and only 0.5-1 mol% of palladium catalysts at 125-150°C, the direct 5-arylation of thiazoles, thiophenes, or furans by using aryl bromides as coupling partners proceeds in moderate to high yields.

Ligand-free palladium-catalyzed direct arylation of thiazoles at low catalyst loadings

Ligand-free Pd(OAc)2 was found to catalyze very efficiently the direct arylation of thiazole derivatives under very low catalyst concentration. By using activated aryl bromides, the reaction can be performed employing as little as 0.1-0.001 mol