1109237-00-4Relevant articles and documents
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure
Chen, Liqiang,Petrelli, Riccardo,Gao, Guangyao,Wilson, Daniel J.,McLean, Garrett T.,Jayaram, Hiremagalur N.,Sham, Yuk Y.,Pankiewicz, Krzysztof W.
experimental part, p. 5950 - 5964 (2010/10/01)
Small molecules that act on multiple biological targets have been proposed to combat the drug resistance commonly observed for cancer chemotherapy. By combining the structural features of known inhibitors of inosine monophosphate dehydrogense (IMPDH) and