110969-41-0

Basic information

• Product Name: Acetyl-(4-tert-butyl-2-nitro-phenyl)-carbamic acid tert-butyl ester
• CAS NO: 110969-41-0
• Molecular Weight: 336.388
• Mol File: 110969-41-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetyl-(4-tert-butyl-2-nitro-phenyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetyl-(4-tert-butyl-2-nitro-phenyl)-carbamic acid tert-butyl ester(110969-41-0)
• EPA Substance Registry System: Acetyl-(4-tert-butyl-2-nitro-phenyl)-carbamic acid tert-butyl ester(110969-41-0)

Safety Data

• Hazardous Substances Data: 110969-41-0(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 40655-37-6 N-(4-(tert-butyl)-2-nitrophenyl)acetamide 

Relevant articles and documents

Selective Cleavage of Boc-acylamides. A Novel Approach to Deacylation of Carboxamides

Boc (tert-butoxycarbonyl) derivatives were recently prepared from various amides.This paper describes some of their properties with particular attention to mild amide cleavage.Boc-protected carboxamides were cleaved by aminolysis with complete selectivity to give the corresponding tert-butyl carbamates.The amines used ranged from hydrazine to morpholine, but for preparative purposes 2-diethylaminoethylamine was preferred.A simple two-step one-pot procedure for tert-butoxycarbonylation followed by aminolysis was developed which could be used for removal of formyl, ace tyl, and benzoyl groups.In extreme cases, there derivatives were cleaved by alcoholysis.Upon addition of bases such as N,N,N',N'-tetramethylguanidine (TMS) this reaction became very fast.TMS-catalysed methanolysis gave 98percent cleavage in 30 min or less in two preparative experiments.