111035-95-1

Basic information

• Product Name: 2-hydroxy-2-ethyl-2-phenylacetonitrile
• CAS NO: 111035-95-1
• Molecular Weight: 161.203
• Mol File: 111035-95-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-2-ethyl-2-phenylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-2-ethyl-2-phenylacetonitrile(111035-95-1)
• EPA Substance Registry System: 2-hydroxy-2-ethyl-2-phenylacetonitrile(111035-95-1)

Safety Data

• Hazardous Substances Data: 111035-95-1(Hazardous Substances Data)

Upstream product

• 74-90-8 hydrogen cyanide 
• 93-55-0 1-phenyl-propan-1-one 
• 143-33-9 sodium cyanide 
• 2039-93-2 1-ethylstyrene 
• 103-65-1 phenylpropane 

Downstream Products

• 74-90-8 hydrogen cyanide 
• 93-55-0 1-phenyl-propan-1-one 
• 52839-87-9 HEPA 
• 298689-33-5 2-amino-2-phenylbutyronitrile 
• 1373618-07-5 5-ethoxy-6-ethyl-6-phenyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one 
• 1373618-22-4 C₁₃H₁₉N₃O₃ 
• 1373617-99-2 C₁₅H₂₂N₂O₄ 
• 1391908-93-2 C₁₂H₁₆O₂S 
• 54444-11-0 cis-2-phenyl-3-methylindanone 
• 54444-14-3 (Z)-1,2-diphenylbut-2-en-1-one 
• 38384-58-6 (E)-1-benzoyl-1-phenylprop-1-ene 
• 2406-21-5 2-hydroxy-2-phenyl-butyric acid ethyl ester 
• 35468-69-0 2-hydroxy-2-phenylbutanoic acid 

Relevant articles and documents

Bifunctional Metal-Organic Layers for Tandem Catalytic Transformations Using Molecular Oxygen and Carbon Dioxide

Tandem catalytic reactions improve atom- and step-economy over traditional synthesis but are limited by the incompatibility of the required catalysts. Herein, we report the design of bifunctional metal-organic layers (MOLs), HfOTf-Fe and HfOTf-Mn, consisting of triflate (OTf)-capped Hf6 secondary building units (SBUs) as strong Lewis acidic centers and metalated TPY ligands as metal active sites for tandem catalytic transformations using O2 and CO2 as coreactants. HfOTf-Fe effectively transforms hydrocarbons into cyanohydrins via tandem oxidation with O2 and silylcyanation whereas HfOTf-Mn converts styrenes into styrene carbonates via tandem epoxidation and CO2 insertion. Density functional theory calculations revealed the involvement of a high-spin FeIV (S = 2) center in the challenging oxidation of the sp3 C-H bond. This work highlights the potential of MOLs as a tunable platform to incorporate multiple catalysts for tandem transformations.

Kinetics of Sodium Borohydride Reduction of α-Substituted Benzyl Phenyl Ketones and Equilibria in Their Cyanohydrin Formation

The rate constants for the sodium borohydride reduction of benzyl phenyl ketone and its α-methoxy, α-acetoxy and α-hydroxy derivatives have been measured in propan-2-ol.The rate data indicate that the introduction of a polar substituent in α-position increases the reaction rate, the order in α-substituents being OMe > OH > OAc > H. α-Acetoxybenzyl phenyl ketone reacts slower than expected because of electronic effects.The observed behaviour is explained on the basis of a conformational effect.The equilibrium constants for the formation of cyanohydrins from the above ketones have also been determined; these are parallel to the rate constants for borohydride reduction.