111064-16-5

Basic information

• Product Name: (Z)-4-(butan-2-ylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
• Synonyms: (Z)-4-(butan-2-ylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
• CAS NO: 111064-16-5
• Molecular Weight: 228.294
• Mol File: 111064-16-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-4-(butan-2-ylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-4-(butan-2-ylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one(111064-16-5)
• EPA Substance Registry System: (Z)-4-(butan-2-ylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one(111064-16-5)

Safety Data

• Hazardous Substances Data: 111064-16-5(Hazardous Substances Data)

Upstream product

• 89-25-8 edaravone 
• 78-93-3 butanone 
• 100-63-0 phenylhydrazine 
• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 

Downstream Products

• 1643537-01-2 (Z)-5-methyl-4-[(3R,4R)-3-methyl-5-nitro-4-phenylpentan-2-ylidene]-2-phenyl-2,4-dihydro-3H-pyrazol-3-one 
• 1643537-02-3 (Z)-5-methyl-4-[(3S,4S)-3-methyl-5-nitro-4-phenylpentan-2-ylidene]-2-phenyl-2,4-dihydro-3H-pyrazol-3-one 
• 1643537-03-4 2,7-dimethyl-2-[(2R,3R)-4-nitro-3-phenylbutan-2-yl]-5-phenyl-1-oxa-5,6-diazaspiro[2.4]hept-6-en-4-one 
• 118661-98-6 11-ethyl-4,10,11-trimethyl-2,8-diphenyl-2,3,8,9-tetraaza-dispiro[4.0.4.1]undeca-3,9-diene-1,7-dione 

Relevant articles and documents

Direct and enantioselective vinylogous michael addition of α-alkylidenepyrazolinones to nitroolefins catalyzed by dual cinchona alkaloid thioureas

While several protocols exist for the asymmetric functionalization of pyrazolinones at the α-position relying on nucleophilic addition or annulation procedures, use of α-alkylidene electron-rich analogues in asymmetric vinylogous coupling to carbon electrophiles is substantially an uncharted domain. We now report, for the first time, that alkylidenepyrazolinones carrying an enolizable carbon at the γ-position efficiently participate in direct and asymmetric, catalytic vinylogous Michael-type additions to nitroolefins providing the expected adducts in high yields, with complete γ-site selectivity and with extraordinary levels of enantio-, diastereo-, and geometrical selectivities. Both enantiomeric adducts were equally accessed by employing a quasi-enantiomeric quinine- or quinidine-based thiourea catalyst pair.