1111643-96-9Relevant articles and documents
Synthesis of novel deuterium labelled derivatives of N-alkylated polyamines
H?kkinen, Merja R.,Kein?nen, Tuomo A.,Khomutov, Alex R.,Auriola, Seppo,Weisell, Janne,Alhonen, Leena,J?nne, Juhani,Veps?l?inen, Jouko
experimental part, p. 547 - 562 (2009/04/07)
Novel di-, tetra- and octadeuterated derivatives of mono-N-alkylated diaminopropanes, spermidines, spermines, symmetrically bis-N-alkylated spermines and unsymmetrically bis-N-alkylated spermines were synthesized. Deuterium labels were introduced into the RHNCH2CH2CN intermediate either by exchanging the protons next to the nitrile group under basic conditions with D2O-EtOD mixture or/and by reducing the nitrile group to a CD2-NH2 fragment with LiAlD4.