1111765-75-3

Basic information

• Product Name: C₂₂H₁₈N₂O₂
• Synonyms: C₂₂H₁₈N₂O₂
• CAS NO: 1111765-75-3
• Molecular Weight: 342.397
• Mol File: 1111765-75-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₈N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₈N₂O₂(1111765-75-3)
• EPA Substance Registry System: C₂₂H₁₈N₂O₂(1111765-75-3)

Safety Data

• Hazardous Substances Data: 1111765-75-3(Hazardous Substances Data)

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 35661-51-9 N-(9-fluorenylmethyloxycarbonyl)hydrazine 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 100-52-7 benzaldehyde 

Downstream Products

• 276672-36-7 (9H-fluoren-9-yl)methyl 2-benzylhydrazinecarboxylate 

Relevant articles and documents

One-Pot Synthesis of Protected Benzylhydrazines from Acetals

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Cyclic aza-peptide integrin ligand synthesis and biological activity

Aza-peptides are obtained by replacement of the α-C-atom of one or more amino acids by a nitrogen atom in a peptide sequence. Introduction of aza-residues into peptide sequences may result in unique structural and pharmacological properties, such that aza-scanning may be used to probe structure-activity relationships. In this study, a general approach for the synthesis of cyclic aza-peptides was developed by modification of strategies for linear aza-peptide synthesis and applied in the preparation of cyclic aza-pentapeptides containing the RGD (Arg-Gly-Asp) sequence. Aza-amino acid scanning was performed on the cyclic RGD-peptide Cilengitide, cyclo[R-G-D-f-N(Me)V] 1, and its parent peptide cyclo(R-G-D-f-V) 2, potent antagonists of the αvβ3, αvβ5, and α5β1 integrin receptors, which play important roles in human tumor metastasis and tumor-induced angiogenesis. Although incorporation of the aza-residues resulted generally in a loss of binding affinity, cyclic aza-peptides containing aza-glycine retained nanomolar activity toward the αvβ3 receptor.

Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill

A large variety of Boc-, Bz-, Ts-, and Fmoc- protected hydrazones were prepared via condensation of an equimolar amount of carbonyl-compound and the corresponding hydrazine using a ball-mill. Hydrazones were always obtained in a quantitative yield and no solvents were used at any step. In a second step, we realized the first solvent-free N-allylation and N-benzylation of these hydrazones.