111263-58-2

Basic information

• Product Name: cis-oxalic acid (trans-1,2-cyclohexanediamine)dihydroxyplatinum(II)
• CAS NO: 111263-58-2
• Molecular Weight: 431.305
• Mol File: 111263-58-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: cis-oxalic acid (trans-1,2-cyclohexanediamine)dihydroxyplatinum(II)(CAS DataBase Reference)
• NIST Chemistry Reference: cis-oxalic acid (trans-1,2-cyclohexanediamine)dihydroxyplatinum(II)(111263-58-2)
• EPA Substance Registry System: cis-oxalic acid (trans-1,2-cyclohexanediamine)dihydroxyplatinum(II)(111263-58-2)

Safety Data

• Hazardous Substances Data: 111263-58-2(Hazardous Substances Data)

Upstream product

• 141610-50-6 oxaliplatin 
• 7722-84-1 dihydrogen peroxide 
• 61825-94-3 Oxaliplatin 
• 61825-94-3 oxaliplatin 

Relevant articles and documents

Platinum(iv) prodrugs with long lipid chains for drug delivery and overcoming cisplatin resistance

Platinum(iv) prodrugs of clinically used cisplatin and oxaliplatin with two axial long lipid chains were developed for nanoparticle delivery to combat cisplatin resistance.

Pegylated ICD inducer-IDO inhibitor nano conjugate as well as preparation method and application thereof

The invention discloses a pegylated ICD inducer-IDO inhibitor nano conjugate as well as a preparation method and application thereof. The structural formula of the pegylated ICD inducer-IDO inhibitornano conjugate is shown in the specification, wherein R is H or a substance shown in the specification, and the weight-average molecular weight is 1000-5000. According to the pegylated ICD inducer-IDOinhibitor nano conjugate provided by the invention, in a water-based medium, a pegylated drug conjugate can be self-assembled into a drug-based nano conjugate. Not only can non-specific accumulationin MPS-related organs be reduced, but also the passive targeting ability to solid tumors is improved through enhanced permeability and retention effect, so that the treatment index is improved.

5 - Fluorouracil - platinum (IV) complex, intermediate, preparation method and application thereof (by machine translation)

The present invention provides 5 - fluoro uracil - platinum (IV) complex, intermediate and preparation method, by formula (1) expressed, wherein Is selected from cisplatin, oxaliplatin, carboplatin, age platinum, nedaplatin or Miboplatin, preferred, For cisplatin or oxaliplatin; R1 For - Cn H2 N -, N is an integer and n ≥ 1, preferred, - Cn H2 N - Straight chain group, R2 For - Cm H2 M + 1 , M is an integer and m ≥ 1, preferred, - Cm H2 M + 1 Straight chain group. The invention of 5 - Fluorouracil - platinum (IV) complex can be reduced cisplatin, oxaliplatin with 5 - Fluorouracil toxic side effect, and at the same time used for the treatment of cancer and in anti-tumor drugs have the synergistic the sensitivity. (by machine translation)