111269-60-4

Basic information

• Product Name: 1,2-Propanedione, 3,3,3-trifluoro-1-(4-methylphenyl)-
• CAS NO: 111269-60-4
• Molecular Formula: C10H7F3O2
• Molecular Weight: 216.16
• Mol File: 111269-60-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-Propanedione, 3,3,3-trifluoro-1-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Propanedione, 3,3,3-trifluoro-1-(4-methylphenyl)-(111269-60-4)
• EPA Substance Registry System: 1,2-Propanedione, 3,3,3-trifluoro-1-(4-methylphenyl)-(111269-60-4)

Safety Data

• Hazardous Substances Data: 111269-60-4(Hazardous Substances Data)

Upstream product

• 111269-40-0 3-(p-tolyl)-1,1,1-trifluoropropane-2,3-dione 3-dimethylhydrazone 
• 75199-80-3 1-(p-methylphenyl)-3,3,3-trifluoro-2-propanone 
• 28925-63-5 p-Methylbenzaldehyd-N,N-dibenzylhydrazon 
• 104-87-0 4-methyl-benzaldehyde 
• 24459-52-7 1,1-dimethyl-2-(4-methylbenzylidene)hydrazine 

Downstream Products

• 133593-18-7 2-(N',N'-Dimethyl-hydrazino)-3,3,3-trifluoro-2-hydroxy-1-p-tolyl-propan-1-one 
• 111269-70-6 5-p-Tolyl-6-trifluoromethyl-pyrazine-2,3-dicarbonitrile 
• 161643-97-6 1,1,1-Trifluoro-3-hydrazono-3-p-tolyl-propan-2-one 
• 133593-25-6 3-(p-tolyl)-1,1,1-trifluoropropane-2,3-dione 2-dimethylhydrazone 
• 129247-46-7 1-Methyl-4-trifluoromethyl-5-(p-tolyl)imidazole 
• 252210-19-8 3,3,3-trifluoro-1-p-tolyl-propane-1,2-dione 1-oxime 
• 111269-69-3 2-(p-tolyl)-3-(trifluoromethyl)quinoxaline 

Relevant articles and documents

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.

Electrophilic Substitution at Azomethine Carbon Atoms. Reaction of Aromatic Aldehyde Hydrazones with Trifluoroacetic Anhydride

Reaction of dimethylhydrazones of aromatic aldehydes with trifluoroacetic anhydride at room temperature affords high yields of products bearing trifluoroacetyl groups.These electrophilic substitution reactions generally occur on the azomethine carbon, although competitive N-acylation is observed in highly electron-rich systems.Use of diisopropylhydrazones suppressed this N-acylation completely, leading to high yields of C-acylated products.The trifluoroacetyl hydrazones can be cyclized thermally to imidazole and oxadiazine derivatives and can be converted into 1-trifluoromethyl 1,2-diketones by acid hydrolysis.