111359-25-2

Basic information

• Product Name: α-(4-methoxy phenyl)-α-hydroxy-N,N dimethylthioacetamide
• Synonyms: α-(4-methoxy phenyl)-α-hydroxy-N,N dimethylthioacetamide
• CAS NO: 111359-25-2
• Molecular Weight: 225.312
• Mol File: 111359-25-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: α-(4-methoxy phenyl)-α-hydroxy-N,N dimethylthioacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: α-(4-methoxy phenyl)-α-hydroxy-N,N dimethylthioacetamide(111359-25-2)
• EPA Substance Registry System: α-(4-methoxy phenyl)-α-hydroxy-N,N dimethylthioacetamide(111359-25-2)

Safety Data

• Hazardous Substances Data: 111359-25-2(Hazardous Substances Data)

Upstream product

• 33646-40-1 4-methoxymandelonitrile 
• 758-16-7 N,N-dimethylthioformamide 
• 7783-06-4 hydrogen sulfide 
• 60-29-7 diethyl ether 
• 123-11-5 4-methoxy-benzaldehyde 
• 75-89-8 2,2,2-trifluoroethanol 
• 16839-97-7 2-methoxythiophene 
• 67-56-1 methanol 

Downstream Products

• 111359-29-6 6-methoxy-N,N-dimethylbenzo[b]thiophen-2-amine 
• 111359-34-3 N,N-dimethyl-2-anisylthioacetamide-2-yl cation 

Relevant articles and documents

Relative reactivities of a strongly nucleophilic alkene and azide ion in aqueous methanol

-

Solvent effects on carbocation - Nucleophile combination reactions: A comparison of π-nucleophilicity in aqueous and organic solvents

The following selectivities are reported for partitioning of the α- (N,N-dimethylthiocarbamoyl)-4-methoxybenzyl carbocation 1+ between nucleophilic addition of π-nucleophiles and a solvent of 50:50 (v:v) acetonitrile/water at 25 °C (nucleophile, k(Nu)/k(s)): pyrrole, 23 M-1; 2- methoxythiophene, ?2 M-1. No nucleophile adducts (+, and they provide support for a simple relationship between the Ritchie N+ scale of nucleophilicity in water and the Mayr N scale of nucleophilicity in weakly polar nonnucleophilic solvents. Our data require a large effective molarity for the intramolecular addition of a trisubstituted alkene to an allylic carbocation.

Benzothiphene derivatives for treating resistant tumors

This invention provides a series of substituted benzo[b]thiophenes useful in reversing multidrug resistance in a resistant neoplasm. The present invention also provides methods for reversing the multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted benzothiophene. This invention also provides methods for treating neoplasms in a mammal which comprises administering to a mammal in need of this treatment a substituted benzothiophene in combination with an oncolytic agent.