111363-79-2

Basic information

• Product Name: benzyl 2-([1,1'-biphenyl]-4-yl)acetate
• Synonyms: benzyl 2-([1,1'-biphenyl]-4-yl)acetate
• CAS NO: 111363-79-2
• Molecular Weight: 302.373
• Mol File: 111363-79-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: benzyl 2-([1,1'-biphenyl]-4-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 2-([1,1'-biphenyl]-4-yl)acetate(111363-79-2)
• EPA Substance Registry System: benzyl 2-([1,1'-biphenyl]-4-yl)acetate(111363-79-2)

Safety Data

• Hazardous Substances Data: 111363-79-2(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 15014-25-2 malonic acid dibenzyl ester 
• 5728-52-9 (4-biphenylyl)acetic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 512176-87-3 benzyl 2-benzoyl-2-(1,1'-biphenyl-4-yl)propanoate 
• 512176-75-9 benzyl 2-benzoyl-2-(1,1'-biphenyl-4-yl)ethanoate 

Relevant articles and documents

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Catalysed asymmetric protonation of simple linear keto-enolic species a route to chiral α-arylpropionic acids

The reaction cascade consisting of deprotection/decarboxylation/asymmetric protonation of enolic species, starting from open-chain benzyl β-oxo esters, has been studied. When carried out in the presence of catalytic amounts of cinchonine, the reaction gave optically active α-aryl ketones with up to 75% ee. Enantio-enriched (S)-3-phenyl-2-butanone can be converted into 2-phenylpropionic acid without racemisation. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.