111391-35-6

Basic information

• Product Name: (E)-3-(4-(benzyloxy)phenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
• Synonyms: (E)-3-(4-(benzyloxy)phenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
• CAS NO: 111391-35-6
• Molecular Weight: 360.409
• Mol File: 111391-35-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-3-(4-(benzyloxy)phenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(4-(benzyloxy)phenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one(111391-35-6)
• EPA Substance Registry System: (E)-3-(4-(benzyloxy)phenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one(111391-35-6)

Safety Data

• Hazardous Substances Data: 111391-35-6(Hazardous Substances Data)

Upstream product

• 4397-53-9 p-benzyloxybenzaldehyde 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 

Downstream Products

• 111391-65-2 2-(4-Benzyloxy-phenyl)-3,7-dimethoxy-chromen-4-one 
• 111391-83-4 2-(4-hydroxyphenyl)-3,7-dimethoxy-4H-chromen-4-one 
• 111391-50-5 2-[4-(benzyloxy)phenyl]-3-hydroxy-7-methoxy-4H-chromen-4-one 

Relevant articles and documents

Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase

A series of new isoliquiritigenin (ISL) derivatives were synthesized and evaluated as dual inhibitors for amyloid-beta (Aβ) aggregation and 5-lipoxygenase (5-LO). It was found that all these synthetic compounds inhibited Aβ (1-42) aggregation effectively with their IC50 values ranged from 2.2 ± 1.5 μM to 23.8 ± 2.0 μM. These derivatives also showed inhibitory activity to 5-LO with their IC50 values ranged from 6.1 ± 0.1 μM to 35.9 ± 0.3 mM. Their structure-activity relationships (SAR) and mechanisms of inhibitions were studied. This study provided potentially important information for further development of ISL derivatives as multifunctional agents for Alzheimer's disease (AD) treatment.