111423-01-9

Basic information

• Product Name: 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5,6,7-tetrahydro-1,5-diphenyl-6-thioxo-
• CAS NO: 111423-01-9
• Molecular Formula: C17H12N4OS
• Molecular Weight: 320.374
• Mol File: 111423-01-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5,6,7-tetrahydro-1,5-diphenyl-6-thioxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5,6,7-tetrahydro-1,5-diphenyl-6-thioxo-(111423-01-9)
• EPA Substance Registry System: 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5,6,7-tetrahydro-1,5-diphenyl-6-thioxo-(111423-01-9)

Safety Data

• Hazardous Substances Data: 111423-01-9(Hazardous Substances Data)

Upstream product

• 16078-71-0 ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate 
• 103-72-0 phenyl isothiocyanate 
• 100-63-0 phenylhydrazine 
• 110810-00-9 5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide 
• 58046-54-1 5-amino-1-phenyl-1H-pyrazole-4-carbohydrazide 
• 62-53-3 aniline 
• 198716-01-7 1-Phenyl-6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d][1,3]thiazin-4-one 
• 701-73-5 methyl N-phenyldithiocarbamate 
• 198715-88-7 5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid [1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 198715-89-8 5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid [1-(4-chloro-phenyl)-meth-(Z)-ylidene]-hydrazide 

Downstream Products

• 113269-23-1 1-Phenyl-1H-9-thia-1,2,4a,10-tetraaza-cyclopenta[b]fluoren-4-one 
• 1152689-66-1 6-hydrazinyl-1,5-diphenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 

Relevant articles and documents

Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line

Some novel 6-substituted pyrazolo[3,4-d]pyrimidines 4, 5, 6a-d, 7a-c, 8 and pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidines 9a-c, 10a-c, 11, 12a,b, 13a-c and 14 were synthesized and characterized by spectral and elemental analyses. They were screened for their biological activity in?vitro against Abl and Src kinases. Compounds 7a and 7b revealed the highest activity against both wild and mutant Abl kinases as well as the Src kinase and the leukemia K-562?cell line. They can be considered as new hits for further structural optimization to obtain better activity.

Syntheis of Some New Pyrazolotriazines, Pyrazolothiazines and Pyrazolopyrimidines

When the pyrazole derivatives 3a,b were treated with triethyl orthoformate, the pyrazolotriazinethiones 5a,b were obtained.These were S-alkylated to give compounds 6a-d.Treatment of 5a,b with hydrazine hydrate in ethanol afforded 7,8 respectively.Benzylid