111437-67-3Relevant articles and documents
Renin Inhibitors. Design and Synthesis of a New Class of Conformationally Restricted Analogues of Angiotensinogen
Sham, Hing L.,Bolis, Giorgio,Stein, Herman H.,Fesik, Stephen W.,Marcotte, Patric A.,et al.
, p. 284 - 295 (2007/10/02)
Molecular modeling methods have been used to design a novel series of conformationally constrained cyclic peptide inhibitors of human renin.Three goals were defined: enhanced inhibitory potency, high specificity for renin, and increased metabolic stabilit