111480-84-3 Usage
Description
2-Chlorosulfonyl-pyridinium, Chloride is an off-white solid that serves as a versatile reactant in the synthesis of various chemical compounds. It is known for its reactivity and ability to form different types of molecules, making it a valuable component in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
2-Chlorosulfonyl-pyridinium, Chloride is used as a reactant for the preparation of benzamides, which act as 11β-hydroxysteroid dehydrogenase type 1 modulators. These modulators are essential in the treatment of metabolic syndromes, a group of conditions that increase the risk of heart disease, stroke, and type 2 diabetes.
Used in Pharmaceutical Industry (continued):
2-Chlorosulfonyl-pyridinium, Chloride is also used in the preparation of piperidine derivatives, which serve as tachykinin receptor antagonists. These antagonists have potential applications in the treatment of various disorders, including asthma, chronic obstructive pulmonary disease (COPD), and migraines, by blocking the action of tachykinins, a group of neuropeptides involved in the transmission of pain signals and inflammation.
Check Digit Verification of cas no
The CAS Registry Mumber 111480-84-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,4,8 and 0 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 111480-84:
(8*1)+(7*1)+(6*1)+(5*4)+(4*8)+(3*0)+(2*8)+(1*4)=93
93 % 10 = 3
So 111480-84-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H4ClNO2S.ClH/c6-10(8,9)5-3-1-2-4-7-5;/h1-4H;1H
111480-84-3Relevant articles and documents
NaClO2-mediated preparation of pyridine-2-sulfonyl chlorides and synthesis of chiral sulfonamides
Xu, Dong,Yang, Shiyi,Gao, Aijun,Yang, Zhanhui
, p. 463 - 473 (2020/07/03)
A simple method to prepare azaarenesulfonyl chlorides by NaClO2-mediated oxidative chlorination of azaarenethiols have been developed, with water as the solvent. Easy purification by simple extraction and concentration gives the products in good yields. The azaarenesulfonyl chlorides readily undergo condensation with chiral amines to afford chiral sulfonamides.
