1114967-84-8Relevant articles and documents
Proline-catalyzed highly enantioselective and anti-selective mannich reaction of unactivated ketones: Synthesis of chiral α-amino acids
Hahn, Bjoern T.,Froehlich, Roland,Harms, Klaus,Glorius, Frank
supporting information; experimental part, p. 9985 - 9988 (2009/04/21)
(Chemical Equation Presented) Universal L-proline: The title reaction complements well-known syn-selective Mannich reactions. The Mannich products can be converted readily into the free amino acids by hydrogenolytic deprotection under mild conditions (see scheme). DMSO = dimethyl sulfoxide; R1 = alkyl, OH; R2 = alkyl.