1115-81-7

Basic information

• Product Name: (R)-(+)-2-METHYLGLUTARIC ACID
• Synonyms: (R)-(+)-2-METHYLGLUTARIC ACID 98+%;(2R)-2-Methylglutaric acid;(2R)-2-Methylpentanedioic acid;(R)-(-)-2-Methylglutaric Acid;(R)-(-)-2-METHYLPENTANEDIOIC ACID;(R)-(-)-2-METHYLGLUTARIC ACID;(R)-(+)-2-METHYLGLUTARIC ACID;(R)-2-METHYLGLUTARIC ACID
• CAS NO: 1115-81-7
• Molecular Formula: C₆H₁₀O₄
• Molecular Weight: 146.14
• Product Categories: Carboxylic Acids (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry
• Mol File: 1115-81-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 83°C
• Boiling Point: 332.7 °C at 760 mmHg
• Flash Point: 148.8 °C
• Appearance: /
• Density: 1.246 g/cm³
• Vapor Pressure: 2.76E-05mmHg at 25°C
• Refractive Index: -21 ° (C=5, H2O)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly)
• PKA: 4.57±0.10(Predicted)
• CAS DataBase Reference: (R)-(+)-2-METHYLGLUTARIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-2-METHYLGLUTARIC ACID(1115-81-7)
• EPA Substance Registry System: (R)-(+)-2-METHYLGLUTARIC ACID(1115-81-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 1115-81-7(Hazardous Substances Data)

Usage

General Description

(R)-(+)-2-Methylglutaric acid is a chemical compound with the molecular formula C6H10O4. It is a derivative of glutaric acid, which is a di-carboxylic acid. The (R)-(+)-2-Methylglutaric acid is an organic compound commonly used as a chiral building block in organic synthesis and as a key intermediate in the production of pharmaceuticals and agrochemicals. It is also utilized in the production of flavors and fragrances. The (R)-(+)-2-Methylglutaric acid is a white crystalline solid with a slight odor and is soluble in water and ethanol. It also has potential applications in the fields of medicine, biochemistry, and chemical research due to its unique structural and chiral properties.

InChI:InChI=1/C6H10O4/c1-4(6(9)10)2-3-5(7)8/h4H,2-3H2,1H3,(H,7,8)(H,9,10)/t4-/m1/s1

Upstream product

• 18069-17-5 2-methylglutaric acid 
• 57-24-9 strychnidin-10-one 
• 62344-97-2 ethyl 4-cyanopentanoate 
• 92621-62-0 1L-(1,2,4/3)-1-Methyl-2,3,4-cyclohexantriol 
• 92857-12-0 (1R,2R,3R)-1-(1ξ-Hydroxy-ethyl)-2-(2-ethyl-3-methyl-butyryl)-3-methyl-cyclopentan 
• 75281-35-5 (-)-trans,cis-nepetonic acid 
• 17948-87-7 (R)-2-Carboxymethyl-5-methyl-cyclopent-1-enecarboxylic acid 
• 2857-75-2 (R)-4-methyl-δ-valerolactone 
• 37779-39-8 (-)-(S)-2-methylpentane-1,5-diol 
• 19479-28-8 (-)-(1R)-1-methoxymyodesert-3-ene 
• 43124-56-7 (+)-isoterpinolene 
• 64-19-7 acetic acid 
• 11005-20-2 Pseudohecogenin 
• 127-09-3 sodium acetate 

Downstream Products

• 33514-22-6 dimethyl (R)-(-)-2-methylglutarate 
• 18545-83-0 (+)-(S)-diethyl 2-methylglutarate 

Relevant articles and documents

MONOTERPENOIDS-VI. ON THE OPTICAL PURITY OF (+)-CAR-3-ENE FROM PINUS ROXBURGHII, AND THE SOURCE OF RACEMIZATION OF (-)-MENTHOL DERIVED THEREFROM

It is shown that (+)-car-3-ene occurring in the oleoresin from Pinus roxburghii is optically pure.It is also demonstrated that in the production of (-)-menthol from (+)-car-3-ene by the MRC process, partial racemization of (-)-menthol has its origin at the stage of (+)-isoterpinolene.

Asymmetric hydrodimerization of styrene by a chiral zirconium complex containing a tetradentate [OSSO]-type bis(phenolato) ligand

The chiral non racemic (Λ,R,R)-[OSSO]Zr(CH2Ph) 2 (1a) activated by methylaluminoxane (MAO) and in presence of H 2 produces the chiral hydrodimer (S)-1,3-diphenylbutane with good selectivity respect to the achiral 1,4-diphenylbutane. The absolute configuration of the chiral dimer and the effect of the hydrogen pressure on the ratio between 1,3-diphenylbutane and 1,4-diphenylbutane give useful information about the regiochemistry and stereochemistry of insertion of the styrene into the Zr-H bond.

Biosynthesis of the myxobacterial antibiotic corallopyronin A

Corallopyronin A is a myxobacterial compound with potent antibacterial activity. Feeding experiments with labelled precursors resulted in the deduction of all biosynthetic building blocks for corallopyronin A and revealed an unusual feature of this metabolite: its biosynthesis from two chains, one solely PKS-derived and the other NRPS/PKS-derived. The starter molecule is believed to be carbonic acid or its monomethyl ester. The putative corallopyronin A biosynthetic gene cluster is a trans-AT-type mixed PKS/NRPS gene cluster, containing a β-branching cassette. Striking features of this gene cluster are a NRPS-like adenylation domain that is part of a PKS-type module and is believed to be responsible for glycine incorporation, as well as split modules with individual domains occurring on different genes. It is suggested that CorB is a transacting ketosynthase and it is proposed that it catalyses the Claisen condensation responsible for the interconnection of the two chains. Additionally, the stereochemistry of corallopyronin A was deduced by a combination of a modified Mosher's method and ozonolysis with subsequent chiral GC analyses.

Sulfated alkenes from the echinus Temnopleurus hardwickii

Three new sulfated alkenes (1-3), trimethylammonium (5R)-5,9-dimethyl-(3E)- 3,8-decadienyl-1-sulfate, dimethylammonium (5R)-5,9-dimethyl-(3E)-3,8- decadienyl-1-sulfate, and 2′-methyl-4′-oxobutan-2-ylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate

Sesterterpenoids from the sponge Sarcotragus sp.

Nineteen new sesterterpenoids and eight known compounds were isolated from the sponge Sarcotragus sp. collected from Soheuksan Island, Korea. The structures of these compounds were determined to be linear sesterterpenoids containing furan or related oxygenated functionalities on the basis of combined chemical and spectroscopic analyses. In addition, the configurations of several previously undetermined compounds were assigned. Several compounds exhibited moderate to major antibacterial activity (compounds 1-3, 17, 18) and cytotoxicity (3, 11, 12) against the K562 cell line and inhibitory activity against isocitrate lyase (6, 13).