111767-82-9

Basic information

• Product Name: (2R,2'S,3'aR,7'S,7'aR,4''S,5''R)-4''-decahydro-4''-<<4-(diphenylphosphino)benzoyl>oxy>-5''-methyldispiro-pyran>-7'-carboxaldehyde
• Synonyms: (2R,2'S,3'aR,7'S,7'aR,4''S,5''R)-4''-decahydro-4''-<<4-(diphenylphosphino)benzoyl>oxy>-5''-methyldispiro-pyran>-7'-carboxaldehyde
• CAS NO: 111767-82-9
• Molecular Weight: 586.621
• Mol File: 111767-82-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,2'S,3'aR,7'S,7'aR,4''S,5''R)-4''-decahydro-4''-<<4-(diphenylphosphino)benzoyl>oxy>-5''-methyldispiro-pyran>-7'-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,2'S,3'aR,7'S,7'aR,4''S,5''R)-4''-decahydro-4''-<<4-(diphenylphosphino)benzoyl>oxy>-5''-methyldispiro-pyran>-7'-carboxaldehyde(111767-82-9)
• EPA Substance Registry System: (2R,2'S,3'aR,7'S,7'aR,4''S,5''R)-4''-decahydro-4''-<<4-(diphenylphosphino)benzoyl>oxy>-5''-methyldispiro-pyran>-7'-carboxaldehyde(111767-82-9)

Safety Data

• Hazardous Substances Data: 111767-82-9(Hazardous Substances Data)

Upstream product

• 97826-93-2 (3R,4S)-5<(tert-butyldimethylsilyl)oxy>3-hydroxy-1-<2(R)-<2(R)-<(4-methoxybenzyl)oxy>-3-cyclohexen-1(S)-yl>oxiranyl>-4-methyl-1-pentanone 
• 124649-54-3 (3R,4S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-1-[(R)-2-((1S,2R)-2-hydroxy-cyclohex-3-enyl)-oxiranyl]-4-methyl-pentan-1-one 
• 97905-62-9 2(S)-<2(R)-<(4-methoxybenzyl)oxy>-3-cyclohexen-1(S)-yl>oxiranemethanol 
• 124649-53-2 (2R,2'R,3'aR,7'aR,4''S,5''S)-4''-hydroxy-5''-methyl-3'a,6',7',7'a,3'',4'',5'',6''-octahydrodispiropyran> 
• 124649-55-4 (2R,2'S,3'aR,7'aR,4''R,5''S)-4''-hydroxy-5''-methyl-3'a,6',7',7'a,3'',4'',5'',6''-octahydrodispiropyran> 
• 97860-62-3 (2R,2'S,3'aR,7'aR,4''S,5''S)-4''-hydroxy-5''-methyl-3'a,6',7',7'a,3'',4'',5'',6''-octahydrodispiropyran> 
• 111692-59-2 (2R,2'S,3'aR,7'aR,4''S,5''R)-4''-<<4-(diphenylphosphino)benzoyl>oxy>-5''-methyl-3'a,6',7',7'a,3'',4'',5'',6''-octahydrodispiro-pyran> 
• 97826-88-5 1-<2(R)-<2(R)-<(4-methoxybenzyl)oxy>-3-cyclohexen-1(S)-yl>oxiranyl>ethanone 
• 97826-92-1 2(R)-<2(R)-<(4-methoxybenzyl)oxy>-3-cyclohexen-1(S)-yl>oxiranecarbaldehyde 
• 124603-89-0 1-{(R)-2-[(1S,2R)-2-(4-Methoxy-benzyloxy)-cyclohex-3-enyl]-oxiranyl}-ethanol 
• 97826-91-0 cis-2-<2-<(4-methoxybenzyl)oxy>-3-cyclohexen-1-yl>-2-propen-1-ol 
• 124603-91-4 (3S,4S)-3,5-Dihydroxy-1-[(R)-2-((1S,2R)-2-hydroxy-cyclohex-3-enyl)-oxiranyl]-4-methyl-pentan-1-one 
• 124603-92-5 (2R,2'S,3'aR,7'aR,5''S)-5''-methyl-4-oxo-3'a,6',7',7'a,3'',4'',5'',6''-octahydrodispiropyran> 
• 2129-31-9 4-diphenylphosphanobenzoic acid 

Relevant articles and documents

Total Synthesis of (+)-Phyllanthocin. Introduction of Intramolecular Hydroformylation for Complex Molecule Functionalization

A 17-step total synthesis of (+)-phyllanthocin (1a) is described.Application of Sharpless'asymetric epoxidation reaction provided access to the diastereo- and enantiomerically pure epoxy ketone 9, a partner in crossed aldol construction.A notably rapid and high-yielding spiroketal equilibration leading to the tetracyclic intermediate 2 was effected with HF in acetonitrile.A Rh(I)-catalyzed hydroformylation was used to introduce the C3 functionality.Studies of intramolecular delivery of the rhodium nucleus to the concave face of the C3-C4 olefin led to a substantial improvement in yield and regioselectivity over the intermolecular version.