111790-43-3

Basic information

• Product Name: N'-[1-(3-Methoxy-phenyl)-eth-(E)-ylidene]-N,N-dimethyl-hydrazine
• Synonyms: N'-[1-(3-Methoxy-phenyl)-eth-(E)-ylidene]-N,N-dimethyl-hydrazine
• CAS NO: 111790-43-3
• Molecular Weight: 192.261
• Mol File: 111790-43-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N'-[1-(3-Methoxy-phenyl)-eth-(E)-ylidene]-N,N-dimethyl-hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: N'-[1-(3-Methoxy-phenyl)-eth-(E)-ylidene]-N,N-dimethyl-hydrazine(111790-43-3)
• EPA Substance Registry System: N'-[1-(3-Methoxy-phenyl)-eth-(E)-ylidene]-N,N-dimethyl-hydrazine(111790-43-3)

Safety Data

• Hazardous Substances Data: 111790-43-3(Hazardous Substances Data)

Upstream product

• 57-14-7 N,N-Dimethylhydrazine 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 

Downstream Products

• 1448862-57-4 C₁₄H₁₇ClN₂O 
• 1448862-27-8 C₁₄H₁₆N₂O 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 

Relevant articles and documents

A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core

A series of potent non-acetylinic negative allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5 NAMs) was developed starting from HTS screening hit 1. Potency was improved via iterative SAR, and physicochemical properties were optimized to deliver orally bioavailable compounds acceptable for in vivo testing. A lead molecule from the series demonstrated dose-dependent activity in the second phase of the rat formalin test from 30 mg/kg, and a preliminary PK/PD relationship was established.