111858-63-0

Basic information

• Product Name: 2(3H)-Benzoxazolone, 6-(4-nitrobenzoyl)-
• CAS NO: 111858-63-0
• Molecular Formula: C14H8N2O5
• Molecular Weight: 284.228
• Mol File: 111858-63-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2(3H)-Benzoxazolone, 6-(4-nitrobenzoyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Benzoxazolone, 6-(4-nitrobenzoyl)-(111858-63-0)
• EPA Substance Registry System: 2(3H)-Benzoxazolone, 6-(4-nitrobenzoyl)-(111858-63-0)

Safety Data

• Hazardous Substances Data: 111858-63-0(Hazardous Substances Data)

Upstream product

• 59-49-4 2-Benzoxazolinone 
• 122-04-3 4-nitro-benzoyl chloride 
• 13787-57-0 3-(4-nitro-benzoyl)-3H-benzooxazol-2-one 
• 62-23-7 4-nitro-benzoic acid 

Downstream Products

• 182325-45-7 3-[6-(4-Nitro-benzoyl)-2-oxo-benzooxazol-3-yl]-propionitrile 
• 99541-47-6 3-(2-Methyl-piperidin-1-ylmethyl)-6-(4-nitro-benzoyl)-3H-benzooxazol-2-one 
• 99552-29-1 3-(4-Methyl-piperidin-1-ylmethyl)-6-(4-nitro-benzoyl)-3H-benzooxazol-2-one 
• 99541-46-5 6-(4-Nitro-benzoyl)-3-piperidin-1-ylmethyl-3H-benzooxazol-2-one 

Relevant articles and documents

CATALYTIC ACYLATION OF BENZOXAZOLIN-3-ONES IN THE PRESENSCE OF ZINC CHLORIDE

In the acylation of benzoxazolin-2-ones by aromatic acid chlorides in the presence of 10-2 mole ZnCl2, the yields of the corresponding 6-aroylbenzoxazolin-2-ones depend on the electronegativity of the acylating agent and the nucleophilicity of

Synthesis and antibacterial and antifungal properties of thiazolinoethyl-2(3H)-benzoxazolone derivatives. II

Cyano derivatives of 6-acyl-2(3H)-benzoxazolones were reacted with cysteamine HCl in ethanol to give the corresponding 6-acyl-3-thiazolinoethyl-2(3H)-benzoxazolones and their antibacterial and antifungal activities were investigated. The chemical structures were proved by means of their IR and 1H-NMR spectra and elemental analysis. Investigation of antimicrobiaI activity of the compounds was carried out by tube dilution and disc techniques using bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853 and Streptococcus faecalis ATCC 29212) and yeast-like fungi (Candida parapsilosis, C albicans, C pseudotropicalis and C stellatoidea). Inhibitory effects were observed for many compounds against S aureus and Bacillus subtilis. Compounds 13 and 15 had minimum inhibitory concentrations (MIC) of 8.4 and 4.2 μg/mL respectively. The antifungal studies against C albicans (10 and 16, MIC = 67.5 μg/mL), C parapsilosis (15, MIC = 67.5 μg/mL) and C stellaatoidea (9, MIC = 67.5 μg/mL) were more successful in comparison.

Synthesis of some new Mannich bases derived from 6-acyl-3-(3,5-dimethylpiperidinomethyl)-2(3H)-benzoxazolones and their biological activities

A number of 6-acyl-3-(3,5-dimethylpiperidinomethyl)-2(3H)-benzoxazolones have been synthesized by Mannich reaction and their antibacterial and antifungal activities have been tested. Their chemical structures have been proved by means of their IR, NMR, mass spectroscopic data and by elementary analysis. Investigation of antimicrobial activity of compounds was done by tube dilution and paper disc techniques using bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Staphylococcus faecalis RSKK 10541) and yeast-like fungi (Candida parapsilosis, Candida albicans, Candida pseudotropicalis, Candida stellatoidea). Among the compounds tested 6-(2-chlorobenzoyl)-3-(3,5-dimethylpiperidinomethyl)-2(3H)-benzoxazolone (Compound 2) and 6-(3-chlorobenzoyl)-3-(3,5-dimethylpiperidinomethyl)-2(3H)-benzoxazolone (Compound 3) showed the most favorable activity.