111875-02-6

Basic information

• Product Name: N-(3,4-dichlorobenzylsulfonyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline
• Synonyms: N-(3,4-dichlorobenzylsulfonyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 111875-02-6
• Molecular Weight: 386.299
• Mol File: 111875-02-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(3,4-dichlorobenzylsulfonyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,4-dichlorobenzylsulfonyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline(111875-02-6)
• EPA Substance Registry System: N-(3,4-dichlorobenzylsulfonyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline(111875-02-6)

Safety Data

• Hazardous Substances Data: 111875-02-6(Hazardous Substances Data)

Upstream product

• 110-88-3 1,3,5-Trioxan 
• 111874-91-0 C-(3,4-Dichloro-phenyl)-N-[2-(4-methoxy-phenyl)-ethyl]-methanesulfonamide 
• 55-81-2 4-Methoxyphenethylamine 
• 111875-15-1 sodium (3,4‐dichlorophenyl)methanesulfonate 
• 85952-30-3 [(3,4-dichlorophenyl)-methyl]sulfonyl chloride 

Downstream Products

• 1745-13-7 7-methoxy-1,2,3,4-tetrahydro-isoquinoline; picrate 
• 43207-78-9 7-methoxy-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Efficient and suitable preparation of N-sulfonyl-1,2,3,4- tetrahydroisoquinolines and ring analogues using recyclable H6P 2W18O62·24H2O/SiO 2 catalyst

Silica gel-supported H6P2W18O 62·24H2O is an efficient and recyclable catalyst for the synthesis of biologically important molecules. Several substituted N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and ring analogues can be prepared in very good yields and purity by direct reaction of N-aralkylsulfonamides and sym-trioxane by a Pictet-Spengler reaction in the presence of a catalytic amount of silica gel-supported H6P2W18O 62·24H2O. Reactions were performed in a low volume of toluene, at 70 °C and for a short time, typically 15 to 30 min. The title heterocyclic compounds were prepared in very good yields (60%-95%) using the described procedure results in a clean and useful alternative, which has the advantages of a greener methodology with operative simplicity, use of a reusable and non-corrosive solid catalyst, soft reaction conditions, low reaction times, and good yields.