1118974-23-4

Basic information

• Product Name: 3-acetyloxybenzyl diethylphosphate
• Synonyms: 3-acetyloxybenzyl diethylphosphate
• CAS NO: 1118974-23-4
• Molecular Weight: 302.264
• Mol File: 1118974-23-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-acetyloxybenzyl diethylphosphate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-acetyloxybenzyl diethylphosphate(1118974-23-4)
• EPA Substance Registry System: 3-acetyloxybenzyl diethylphosphate(1118974-23-4)

Safety Data

• Hazardous Substances Data: 1118974-23-4(Hazardous Substances Data)

Upstream product

• 78957-20-7 3-(hydroxymethyl)phenyl acetate 
• 814-49-3 diethyl chlorophosphate 
• 620-24-6 3-Hydroxybenzyl alcohol 

Relevant articles and documents

Synthesis and biological activity of acetyl-protected hydroxybenzyl diethyl phosphates (EHBP) as potential chemotherapeutic agents

Several acetyl-protected hydroxybenzyl diethyl phosphates (EHBPs) that are capable of forming quinone methide intermediates were synthesized and their cell growth inhibitory properties were evaluated in four different human cancer cell lines. Compounds 1, 1a, and 1b, corresponding to (4-acetyloxybenzyl diethylphosphate), (3-methyl-4-acetyloxybenzyl diethylphosphate), and (3-chloro-4-acetyloxybenzyl diethylphosphate), were significantly more potent than compounds 2 and 3, (2-acetyloxybenzyl diethylphosphate) and (3-acetyloxybenzyl diethylphosphate), respectively. Using HT-29 human colon cancer cells, compounds 1 and 3 increased apoptosis, inhibited proliferation, and caused a G2/M block in the cell cycle. Our data suggest that these compounds merit further investigation as potential anti-cancer agents.