1119076-06-0Relevant articles and documents
Design, synthesis, nitric oxide release and antibacterial evaluation of novel nitrated ocotillol-type derivatives
Bi, Yi,Yang, Xiao,Zhang, Tingting,Liu, Zeyun,Zhang, Xiaochen,Lu, Jing,Cheng, Keguang,Xu, Jinyi,Wang, Hongbo,Lv, Guangyao,Lewis, Peter John,Meng, Qingguo,Ma, Cong
, p. 71 - 80 (2015)
Abstract Nitric oxide (NO) and its auto-oxidation products are known to disrupt normal bacterial function and NO releasing molecules have the potential to be developed as antibacterial leads in drug discovery. We have designed and synthesized a series of
Design, synthesis and biological evaluation of novel α-hederagenin derivatives with anticancer activity
Liu, Xian-xuan,Yang, Yan-ting,Wang, Xiao,Wang, Kai-yi,Liu, Jia-qi,Lei, Lei,Luo, Xiao-min,Zhai, Rong,Fu, Feng-hua,Wang, Hong-bo,Bi, Yi
, p. 427 - 439 (2017/10/17)
In an attempt to arrive at a more potent cytotoxic agent than the parent compound α-hederagenin (H), 24 α-hederagenin derivatives (5–8, 11–24, 27–28, 31–32, and 35–36) were synthesized in a concise and efficient strategy and screened for in vitro cytotoxicity against the human cancer cell lines MKN45 and KB. Among these compounds, the polyamine derivative 15 exhibited more potency than the parent compound with IC50 values in the range of 4.22 μM–8.05 μM. Compound 15 increased Bax/bcl-2 ratio that disrupted the mitochondrial potential and induced apoptosis. Therefore, the present studies highlight the importance of polyamine derivatives of α-hederagenin in the discovery and development of novel anticancer agents.
